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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mavstm1Camb
targeted mutation 1, John C Cambier
MGI:5308082
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mavstm1Camb/Mavstm1Camb involves: 129S6/SvEvTac * C57BL/6 MGI:5308089


Genotype
MGI:5308089
hm1
Allelic
Composition		 Mavstm1Camb/Mavstm1Camb
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mavstm1Camb mutation (0 available); any Mavs mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal B cell calcium ion homeostasis ( J:180356 )
• anti-IgM-stimulated B cells exhibit slightly elevated calcium flux compared with wild-type mice

immune system
decreased B cell proliferation ( J:180356 )
• in response to LOX and R848 but not CpG
abnormal B cell calcium ion homeostasis ( J:180356 )
• anti-IgM-stimulated B cells exhibit slightly elevated calcium flux compared with wild-type mice
decreased interleukin-12 secretion ( J:180356 )
• in B cells from LOX-treated mice
decreased tumor necrosis factor secretion ( J:180356 )
• in B cells from LOX-treated mice

hematopoietic system
decreased B cell proliferation ( J:180356 )
• in response to LOX and R848 but not CpG
abnormal B cell calcium ion homeostasis ( J:180356 )
• anti-IgM-stimulated B cells exhibit slightly elevated calcium flux compared with wild-type mice

cellular
decreased B cell proliferation ( J:180356 )
• in response to LOX and R848 but not CpG




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory