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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lbrlym3
lymphocyte affected 3
MGI:5308091
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lbrlym3/Lbrlym3 C57BL/6-Lbrlym3 MGI:5308443
ht2
 		Lbrlym3/Lbr+ C57BL/6-Lbrlym3 MGI:5308444
ht3
 		Lbric-J/Lbrlym3 C57BL/6-Lbric-J/Lbrlym3 MGI:5308445


Genotype
MGI:5308443
hm1
Allelic
Composition		 Lbrlym3/Lbrlym3
Genetic
Background		 C57BL/6-Lbrlym3
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lbrlym3 mutation (0 available); any Lbr mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
thymus hypoplasia ( J:180355 )
• at 2 months but not 4 months
abnormal neutrophil morphology ( J:180355 )
• reduced lobularity with some bilobed and ovoid nuclei
decreased leukocyte cell number ( J:180355 )
• profound and progressive lymphopenia
abnormal lymphocyte morphology ( J:180355 )
• pyknotic with signs of blebbing and nuclear clumping
abnormal lymphocyte cell number ( J:180355 )
• mice exhibit a decrease T to B cell ratio compared with wild-type mice
decreased lymphocyte cell number ( J:180355 )
• profound and progressive lymphopenia
• repopulation assays confirm that lymphopenia is cell intrinsic
decreased B cell number ( J:180355 )
• in the spleen and lymph node at 2 months
decreased T cell number ( J:180355 )
• to a greater extent than B cells
decreased CD4-positive, alpha-beta T cell number ( J:180355 )
• in the spleen and lymph node at 2 months
decreased CD8-positive, alpha-beta T cell number ( J:180355 )
• in the spleen and lymph node at 2 months
spleen hypoplasia ( J:180355 )
• at 2 and 4 months
abnormal B cell physiology ( J:180355 )
• B cells exhibit an increase in surface IgM
abnormal T cell physiology ( J:180355 )
• non-dividing lymphocyte lifespan is reduced
lymph node hypoplasia ( J:180355 )
• at 2 and 4 months

skeleton
skeleton phenotype ( J:180355 )
N
• mice exhibit nor obvious skeletal abnormalities

hematopoietic system
thymus hypoplasia ( J:180355 )
• at 2 months but not 4 months
abnormal blood cell morphology/development ( J:180355 )
• bone marrow cells used to re-constitute irradiated wild-type mice are deficient in restoring neutrophils, eosinophils, and red blood cells
abnormal neutrophil morphology ( J:180355 )
• reduced lobularity with some bilobed and ovoid nuclei
decreased leukocyte cell number ( J:180355 )
• profound and progressive lymphopenia
abnormal lymphocyte morphology ( J:180355 )
• pyknotic with signs of blebbing and nuclear clumping
abnormal lymphocyte cell number ( J:180355 )
• mice exhibit a decrease T to B cell ratio compared with wild-type mice
decreased lymphocyte cell number ( J:180355 )
• profound and progressive lymphopenia
• repopulation assays confirm that lymphopenia is cell intrinsic
decreased B cell number ( J:180355 )
• in the spleen and lymph node at 2 months
decreased T cell number ( J:180355 )
• to a greater extent than B cells
decreased CD4-positive, alpha-beta T cell number ( J:180355 )
• in the spleen and lymph node at 2 months
decreased CD8-positive, alpha-beta T cell number ( J:180355 )
• in the spleen and lymph node at 2 months
spleen hypoplasia ( J:180355 )
• at 2 and 4 months
abnormal B cell physiology ( J:180355 )
• B cells exhibit an increase in surface IgM
abnormal T cell physiology ( J:180355 )
• non-dividing lymphocyte lifespan is reduced

endocrine/exocrine glands
thymus hypoplasia ( J:180355 )
• at 2 months but not 4 months

cellular




Genotype
MGI:5308444
ht2
Allelic
Composition		 Lbrlym3/Lbr+
Genetic
Background		 C57BL/6-Lbrlym3
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lbrlym3 mutation (0 available); any Lbr mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal neutrophil morphology ( J:180355 )
• reduced lobularity but not as profound as in homozygous mice

hematopoietic system
abnormal neutrophil morphology ( J:180355 )
• reduced lobularity but not as profound as in homozygous mice




Genotype
MGI:5308445
ht3
Allelic
Composition		 Lbric-J/Lbrlym3
Genetic
Background		 C57BL/6-Lbric-J/Lbrlym3
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lbric-J mutation (1 available); any Lbr mutation (57 available)
Lbrlym3 mutation (0 available); any Lbr mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:180355 )
N
• mice are viable

immune system

hematopoietic system




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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory