All Phenotypes Tg(CAG-GARS)DRwb MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(CAG-GARS)DRwb
transgene insertion D, Robert W Burgess
MGI:5308112

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Gars1^C201R/Gars1^{Gt(XM256)6Byg} Tg(CAG-GARS)DRwb/0	involves: 129P2/OlaHsd * BALB/cAnN * C3H/HeH * C57BL/6J * FVB/N	MGI:5308219
cx2	Gars1^C201R/Gars1⁺ Tg(CAG-GARS)DRwb/0	involves: BALB/cAnN * C3H/HeH * C57BL/6J * FVB/N	MGI:5308216
cx3	Gars1^C201R/Gars1^C201R Tg(CAG-GARS)DRwb/0	involves: BALB/cAnN * C3H/HeH * C57BL/6J * FVB/N	MGI:5308222
cx4	Gars1^C201R/Gars1^Nmf249 Tg(CAG-GARS)DRwb/0	involves: BALB/cAnN * C3H/HeH * C57BL/6J * FVB/N	MGI:5308233
cx5	Gars1^Nmf249/Gars1⁺ Tg(CAG-GARS)DRwb/0	involves: C57BL/6J * CAST/Ei * FVB/N	MGI:5308213

Allelic Composition	Gars1^C201R/Gars1^{Gt(XM256)6Byg} Tg(CAG-GARS)DRwb/0
Genetic Background	involves: 129P2/OlaHsd * BALB/cAnN * C3H/HeH * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gars1^C201R mutation (2 available); any Gars1 mutation (42 available)
Gars1^{Gt(XM256)6Byg} mutation (0 available); any Gars1 mutation (42 available)
Tg(CAG-GARS)DRwb mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:179811 )

N	• mutants are born at the expected Mendelian ratios, indicating rescue of the embryonic lethality observed in compound heterozygotes without the transgene • while embryonic lethality is rescued with the transgene, severity of neuropathy is similar to single Gars^C201R heterozygotes

growth/size/body

decreased body weight ( J:179811 )

• mutants exhibit lower body weights than single Gars^{Gt(XM256)6Byg} heterozygotes or wild-type mice

nervous system

nervous system phenotype ( J:179811 )

N	• mutants exhibit normal numbers of myelinated axons in the motor or sensory branch of the fremoral nerve

abnormal neuromuscular synapse morphology ( J:179811 )

• neuromuscular junctions have regions of immature morphology or denervation, similar to single Gars^C201R heterozygotes

decreased nerve conduction velocity ( J:179811 )

• mutants exhibit reduced nerve conduction velocities, but they are similar to single Gars^C201R heterozygotes

Allelic Composition	Gars1^C201R/Gars1⁺ Tg(CAG-GARS)DRwb/0
Genetic Background	involves: BALB/cAnN * C3H/HeH * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gars1^C201R mutation (2 available); any Gars1 mutation (42 available)
Tg(CAG-GARS)DRwb mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased grip strength ( J:179811 )

• mutants exhibit a similar wire hanging deficit as single Gars^C201R heterozygotes

nervous system

decreased nerve conduction velocity ( J:179811 )

• nerve conduction velocities are reduced to a similar extent as in single Gars^C201R heterozygotes

Allelic Composition	Gars1^C201R/Gars1^C201R Tg(CAG-GARS)DRwb/0
Genetic Background	involves: BALB/cAnN * C3H/HeH * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gars1^C201R mutation (2 available); any Gars1 mutation (42 available)
Tg(CAG-GARS)DRwb mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:179811 )

N	• mutants are born at the expected Mendelian ratios, indicating rescue of the prenatal lethality seen in homozygotes

postnatal lethality, complete penetrance ( J:179811 )

• mutants live to a maximum of P20

growth/size/body

decreased body weight ( J:179811 )

nervous system

abnormal axon morphology ( J:179811 )

• mutants exhibit a 50% reduction in axon numbers in the motor branch of the femoral nerve

abnormal neuromuscular synapse morphology ( J:179811 )

• mutants exhibit neuromuscular junction defects, with frank denervation at almost half of the postsynaptic sites

decreased nerve conduction velocity ( J:179811 )

• impaired nerve conduction velocities

Allelic Composition	Gars1^C201R/Gars1^Nmf249 Tg(CAG-GARS)DRwb/0
Genetic Background	involves: BALB/cAnN * C3H/HeH * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gars1^C201R mutation (2 available); any Gars1 mutation (42 available)
Gars1^Nmf249 mutation (1 available); any Gars1 mutation (42 available)
Tg(CAG-GARS)DRwb mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:179811 )

N	• mutants are viable and born at the expected Mendelian ratios

growth/size/body

decreased body weight ( J:179811 )

• decreased body weight compared to Gars^C201R heterozygotes

nervous system

abnormal axon morphology ( J:179811 )

• the motor branch of the femoral nerve is smaller and axon numbers are reduced

abnormal neuromuscular synapse morphology ( J:179811 )

• mutants exhibit more severe neuromuscular junction defects than either allele as a heterozygote, with a majority of NMJs partially or fully denervated and very few that are fully innervated

Allelic Composition	Gars1^Nmf249/Gars1⁺ Tg(CAG-GARS)DRwb/0
Genetic Background	involves: C57BL/6J * CAST/Ei * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gars1^Nmf249 mutation (1 available); any Gars1 mutation (42 available)
Tg(CAG-GARS)DRwb mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:179811 )

• mutants exhibit a similar decrease in body weight as single Gars^Nmf249 heterozygotes

nervous system

abnormal axon morphology ( J:179811 )

• mutants exhibit a similar reduction in axon numbers in motor and sensory nerves as single Gars^Nmf249 heterozygotes

abnormal neuromuscular synapse morphology ( J:179811 )

• neuromuscular junctions are disrupted to a similar extent as in Gars^Nmf249 heterozygotes

decreased nerve conduction velocity ( J:179811 )

• nerve conduction velocities are similar to single Gars^Nmf249 heterozygotes

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