Phenotypes associated with this allele

• Allele Symbol: Siglech^tm1.1Ksat
• Allele Name: targeted mutation 1.1, Katsuaki Sato
• Allele ID: MGI:5308226
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Siglech^tm1.1Ksat/Siglech^tm1.1Ksat	B6.Cg-Siglech^tm1.1Ksat	MGI:5308366

Genotype
MGI:5308366

hm1

• Allelic Composition: Siglech^tm1.1Ksat/Siglech^tm1.1Ksat
• Genetic Background: B6.Cg-Siglech^tm1.1Ksat

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to infection induced morbidity/mortality ( J:179283 )

• in mice with diphtheria toxin induced plasmacytoid dendritic cell ablation survival is improved following lethal shock trigger by CpG-A in D-galactosamine (D-GalN)-sensitized mice

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:179283 )

• plasmacytoid dendritic cell ablated mutant mice are resistant to infection with Listeria monocytogenes expressing OVA

• plasmacytoid dendritic cell ablated mutant mice show increased numbers of CD11c+B22- dendritic cells and lower bacterial burden 3 days after infection with Listeria monocytogenes expressing OVA

immune system

decreased plasmacytoid dendritic cell number ( J:179283 )

• by 2 days after treatment with diphtheria toxin plasmacytoid dendritic cells are almost completely ablated but numbers rebound by 10 days after treatment

decreased T-helper 17 cell number ( J:179283 )

• in mutant mice

increased T-helper 17 cell number ( J:179283 )

• markedly enhanced in plasmacytoid dendritic cell ablated mutant mice

abnormal regulatory T cell morphology ( J:179283 )

• slightly higher frequency and number of thymic CD4+Foxp3+ regulatory T cells in mutant mice and in plasmacytoid dendritic cell ablated mutant mice compared to wild-type controls

• decrease in the number of CD4+Foxp3+ regulatory T cells in the lamina propria of the small intestine in plasmacytoid dendritic cell ablated mice compared to wild-type controls

abnormal circulating cytokine level ( J:179283 )

• increase in serum cytokines after injection with CpG-A plus D-GalN

• decrease in serum cytokines in plasmacytoid dendritic cell ablated mice following treatment with CpG-A compared to wild-type controls

decreased circulating interferon-alpha level ( J:179283 )

• in plasmacytoid dendritic cell ablated mice following treatment with CpG-A or infection with HSV-1 compared to wild-type controls

increased circulating interferon-alpha level ( J:179283 )

• CpG-A induced and HSV-1 induced IFNA production is enhanced compared to wild-type controls

decreased circulating interleukin-12b level ( J:179283 )

• in plasmacytoid dendritic cell ablated mice following treatment with CpG-A or infection with HSV-1 compared to wild-type controls

increased circulating interleukin-12b level ( J:179283 )

• CpG-A induced and HSV-1 IL12B production is enhanced compared to wild-type controls

abnormal dendritic cell antigen presentation ( J:179283 )

• reduced capacity to present OVA protein and peptide for priming of Tg(TcraTcrb)425Cbn CD4+ T cells in culture

abnormal plasmacytoid dendritic cell physiology ( J:179283 )

• reduced cell surface levels of SIGLECH and B220 and increased levels of CD11C and BST2

• increased production of IFNA and IL12B

decreased susceptibility to infection induced morbidity/mortality ( J:179283 )

• in mice with diphtheria toxin induced plasmacytoid dendritic cell ablation survival is improved following lethal shock trigger by CpG-A in D-galactosamine (D-GalN)-sensitized mice

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:179283 )

• plasmacytoid dendritic cell ablated mutant mice are resistant to infection with Listeria monocytogenes expressing OVA

• plasmacytoid dendritic cell ablated mutant mice show increased numbers of CD11c+B22- dendritic cells and lower bacterial burden 3 days after infection with Listeria monocytogenes expressing OVA

homeostasis/metabolism

abnormal circulating cytokine level ( J:179283 )

• increase in serum cytokines after injection with CpG-A plus D-GalN

• decrease in serum cytokines in plasmacytoid dendritic cell ablated mice following treatment with CpG-A compared to wild-type controls

decreased circulating interferon-alpha level ( J:179283 )

• in plasmacytoid dendritic cell ablated mice following treatment with CpG-A or infection with HSV-1 compared to wild-type controls

increased circulating interferon-alpha level ( J:179283 )

• CpG-A induced and HSV-1 induced IFNA production is enhanced compared to wild-type controls

decreased circulating interleukin-12b level ( J:179283 )

• in plasmacytoid dendritic cell ablated mice following treatment with CpG-A or infection with HSV-1 compared to wild-type controls

increased circulating interleukin-12b level ( J:179283 )

• CpG-A induced and HSV-1 IL12B production is enhanced compared to wild-type controls

hematopoietic system

decreased plasmacytoid dendritic cell number ( J:179283 )

• by 2 days after treatment with diphtheria toxin plasmacytoid dendritic cells are almost completely ablated but numbers rebound by 10 days after treatment

decreased T-helper 17 cell number ( J:179283 )

• in mutant mice

increased T-helper 17 cell number ( J:179283 )

• markedly enhanced in plasmacytoid dendritic cell ablated mutant mice

abnormal regulatory T cell morphology ( J:179283 )

• slightly higher frequency and number of thymic CD4+Foxp3+ regulatory T cells in mutant mice and in plasmacytoid dendritic cell ablated mutant mice compared to wild-type controls

• decrease in the number of CD4+Foxp3+ regulatory T cells in the lamina propria of the small intestine in plasmacytoid dendritic cell ablated mice compared to wild-type controls