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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tsc22d3tm1.1Ric
targeted mutation 1.1, Carlo Riccardi
MGI:5308358
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ot1
 		Tsc22d3tm1.1Ric/Y involves: 129S7/SvEvBrd * C57BL/6 MGI:5308361


Genotype
MGI:5308361
ot1
Allelic
Composition		 Tsc22d3tm1.1Ric/Y
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tsc22d3tm1.1Ric mutation (0 available); any Tsc22d3 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
decreased male germ cell number ( J:179667 )
• numbers reduced at 7 days of age and significantly reduced at 14 days
abnormal testis size ( J:179667 )
• weight reduced 70-80%
azoospermia ( J:179667 )
• adult male testes are devoid of sperm
abnormal spermatid morphology ( J:179667 )
• round spermatids are never found in testes at 21 days of age
arrest of male meiosis ( J:179667 )
• massive apoptosis observed at 14 days when cells are passing through pachytene stage
abnormal spermatogonia proliferation ( J:179667 )
• undifferentiated spermatogonia differentiate more rapidly than in controls
male infertility ( J:179667 )
• males are sterile

endocrine/exocrine glands
abnormal testis size ( J:179667 )
• weight reduced 70-80%

cellular
abnormal spermatid morphology ( J:179667 )
• round spermatids are never found in testes at 21 days of age
decreased male germ cell number ( J:179667 )
• numbers reduced at 7 days of age and significantly reduced at 14 days
azoospermia ( J:179667 )
• adult male testes are devoid of sperm
arrest of male meiosis ( J:179667 )
• massive apoptosis observed at 14 days when cells are passing through pachytene stage
abnormal spermatogonia proliferation ( J:179667 )
• undifferentiated spermatogonia differentiate more rapidly than in controls




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory