Phenotypes associated with this allele

• Allele Symbol: Tnni3^tm1.1Jdp
• Allele Name: targeted mutation 1.1, James Potter
• Allele ID: MGI:5308372
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnni3^tm1.1Jdp/Tnni3^tm1.1Jdp	involves: 129S6/SvEvTac * C57BL/6	MGI:5308375

Genotype
MGI:5308375

hm1

• Allelic Composition: Tnni3^tm1.1Jdp/Tnni3^tm1.1Jdp
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cardiac hypertrophy in Tnni3^tm1.1Jdp/Tnni3^tm1.1Jdp hearts

mortality/aging

mortality/aging ( J:180606 )

N • homozygous mice live at least 18 months

cardiovascular system

cardiovascular system phenotype ( J:180606 )

N • cardiac morphology is normal at 3 and 6 months of age

thick interventricular septum ( J:180606 )

• by 12 months of age

increased heart weight ( J:180606 )

• heart/body weight ratio is increased by 12 months of age

thick ventricular wall ( J:180606 )

• increased left ventricle wall thickness at 12 mongths of age

cardiac interstitial fibrosis ( J:180606 )

• pronounced interstitial fibrosis by 12 months of age

growth/size/body

increased heart weight ( J:180606 )

• heart/body weight ratio is increased by 12 months of age

cellular

cardiac interstitial fibrosis ( J:180606 )

• pronounced interstitial fibrosis by 12 months of age