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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lair1tm1Jco
targeted mutation 1, John E Coligan
MGI:5308462
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lair1tm1Jco/Lair1tm1Jco B6.Cg-Lair1tm1Jco MGI:5308464
cn2
 		Lair1tm1Jco/Lair1tm1Jco
Tg(Cd4-cre)1Cwi/? 		involves: C57BL/6 * DBA/2 MGI:5309018


Genotype
MGI:5308464
hm1
Allelic
Composition		 Lair1tm1Jco/Lair1tm1Jco
Genetic
Background		 B6.Cg-Lair1tm1Jco
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lair1tm1Jco mutation (1 available); any Lair1 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:5309018
cn2
Allelic
Composition		 Lair1tm1Jco/Lair1tm1Jco
Tg(Cd4-cre)1Cwi/?
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lair1tm1Jco mutation (1 available); any Lair1 mutation (37 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgG2a level ( J:180203 )
• significant decrease in IgG2a levels in response to TNP-OVA immunization as compared to control
decreased IgG2b level ( J:180203 )
• significant decrease in IgG2b levels in response to TNP-OVA immunization as compared to control

hematopoietic system
decreased IgG2a level ( J:180203 )
• significant decrease in IgG2a levels in response to TNP-OVA immunization as compared to control
decreased IgG2b level ( J:180203 )
• significant decrease in IgG2b levels in response to TNP-OVA immunization as compared to control




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory