Phenotypes associated with this allele

• Allele Symbol: Lair1^tm1.1Jco
• Allele Name: targeted mutation 1.1, John E Coligan
• Allele ID: MGI:5308465
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lair1^tm1.1Jco/Lair1^tm1.1Jco	involves: C57BL/6	MGI:5309012

Genotype
MGI:5309012

hm1

• Allelic Composition: Lair1^tm1.1Jco/Lair1^tm1.1Jco
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased thymocyte number ( J:180203 )

• slight, but significant, decrease in splenic CD3+ T cells in both young (2-4 months) and old (over 12 months) mice

increased eosinophil cell number ( J:180203 )

• eosinophil number is increased 2 fold in young, but not in old mice

increased dendritic cell number ( J:180203 )

• increase in conventional dendritic cells (cDC) in spleen and bone marrow (22% and 13%, respectively) in young (2-4 months) mice

• plasmacytoid dendritic cell (pDC) number is similar to control

increased B cell number ( J:180203 )

• 10% increase in splenic B cells in young (2-4 months) mice

increased marginal zone B cell number ( J:180203 )

• in young (2-4 months) and old (over 12 months) mice

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:180203 )

• 23% increase in CD4+ CD25+ T cells in young (2-4 months) mice

increased CD4-positive, alpha-beta memory T cell number ( J:180203 )

• in older mice (>12 months)

decreased CD4-positive, alpha-beta T cell number ( J:180203 )

• 10% decrease in CD4+ splenic T cells in young (2-4 months) mice

• naive CD4+ T cells are decreased in mice older than 12 months

increased CD8-positive, alpha-beta memory T cell number ( J:180203 )

• in older mice (>12 months)

decreased CD8-positive, alpha-beta T cell number ( J:180203 )

• 13% decrease in CD8+ T cells in young (2-4 months) mice

• naive CD8+ T cells are decreased in mice older than 12 months

increased activated T cell number ( J:180203 )

• older mice (> 12 months) exhibit increased CD69 expression on CD4+ and CD8+ T cells (20% and 40%, respectively)

decreased IgG1 level ( J:180203 )

• 23% decrease in IgG1 level in 13 month old mice

hematopoietic system

decreased thymocyte number ( J:180203 )

• slight, but significant, decrease in splenic CD3+ T cells in both young (2-4 months) and old (over 12 months) mice

increased eosinophil cell number ( J:180203 )

• eosinophil number is increased 2 fold in young, but not in old mice

thrombocytosis ( J:180203 )

• platelet numbers are slightly elevated in older mice

increased dendritic cell number ( J:180203 )

• increase in conventional dendritic cells (cDC) in spleen and bone marrow (22% and 13%, respectively) in young (2-4 months) mice

• plasmacytoid dendritic cell (pDC) number is similar to control

increased B cell number ( J:180203 )

• 10% increase in splenic B cells in young (2-4 months) mice

increased marginal zone B cell number ( J:180203 )

• in young (2-4 months) and old (over 12 months) mice

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:180203 )

• 23% increase in CD4+ CD25+ T cells in young (2-4 months) mice

increased CD4-positive, alpha-beta memory T cell number ( J:180203 )

• in older mice (>12 months)

decreased CD4-positive, alpha-beta T cell number ( J:180203 )

• 10% decrease in CD4+ splenic T cells in young (2-4 months) mice

• naive CD4+ T cells are decreased in mice older than 12 months

increased CD8-positive, alpha-beta memory T cell number ( J:180203 )

• in older mice (>12 months)

decreased CD8-positive, alpha-beta T cell number ( J:180203 )

• 13% decrease in CD8+ T cells in young (2-4 months) mice

• naive CD8+ T cells are decreased in mice older than 12 months

increased activated T cell number ( J:180203 )

• older mice (> 12 months) exhibit increased CD69 expression on CD4+ and CD8+ T cells (20% and 40%, respectively)

decreased IgG1 level ( J:180203 )

• 23% decrease in IgG1 level in 13 month old mice

endocrine/exocrine glands

decreased thymocyte number ( J:180203 )

• slight, but significant, decrease in splenic CD3+ T cells in both young (2-4 months) and old (over 12 months) mice