Phenotypes associated with this allele

• Allele Symbol: Dnase1l2^tm1Eckh
• Allele Name: targeted mutation 1, Leopold Eckhart
• Allele ID: MGI:5308556
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dnase1l2^tm1Eckh/Dnase1l2^tm1Eckh	involves: 129S6/SvEvTac	MGI:5308593

Genotype
MGI:5308593

hm1

• Allelic Composition: Dnase1l2^tm1Eckh/Dnase1l2^tm1Eckh
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell nucleus morphology ( J:180935 )

• aberrant DNA retention in papillae of the tongue, epithelium of the esophagus, tail scales, hair and nails

• in nails 2000X more nuclear DNA and 30X more mtDNA is present than in controls

integument

abnormal hair shaft morphology ( J:180935 )

• abnormal hair corneocyte morphology

• packing of keratin filaments is disturbed

• hair breaks down under mechanical stress into smaller fragments than does wild type hair

abnormal nail morphology ( J:180935 )

• 2000X more nuclear DNA and 30X more mtDNA is present than in controls