Phenotypes associated with this allele

• Allele Symbol: Pax7^{tm1.1(HBEGF,-EYFP)Mal}
• Allele Name: targeted mutation 1.1, Bernard Malissen
• Allele ID: MGI:5308728
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pax7^tm1.1(HBEGF,-EYFP)Mal/Pax7^tm1.1(HBEGF,-EYFP)Mal	involves: C57BL/6	MGI:5308740
ht2	Pax7^tm1.1(HBEGF,-EYFP)Mal/Pax7^+	involves: C57BL/6	MGI:5308741
cx3	Pax7^tm1.1(HBEGF,-EYFP)Mal/Pax7^+ Tg(Pax7-EGFP)15Tajb/0	involves: C57BL/6 * SJL/J	MGI:5308742

Genotype
MGI:5308740

hm1

• Allelic Composition: Pax7^{tm1.1(HBEGF,-EYFP)Mal}/Pax7^{tm1.1(HBEGF,-EYFP)Mal}
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:180899 )

• mice die during young adulthood

growth/size/body

decreased birth body size ( J:180899 )

Genotype
MGI:5308741

ht2

• Allelic Composition: Pax7^{tm1.1(HBEGF,-EYFP)Mal}/Pax7⁺
• Genetic Background: involves: C57BL/6

muscle

muscle phenotype ( J:180899 )

N • diphtheria toxin-treated mice retain multipotent fibroblastic/adipogenic mesenchymal progenitors

myositis ( J:180899 )

• diphtheria toxin-treated mice exhibit modest cellular interstitial infiltration (primarily macrophagic) in muscles unlike in similarly treated wild-type mice

decreased skeletal muscle mass ( J:180899 )

• in diphtheria-treated muscles, even following diphtheria toxin depletion

impaired skeletal muscle regeneration ( J:180899 )

• mice treated with diphtheria and cardiotoxin exhibit impaired muscle regeneration with massive tissue infiltration, loss of myofibres and failure to reconstitute skeletal muscle tissue structure and mass compared with similarly treated wild-type mice

• following treatment and depletion of diphtheria toxin, cardiotoxin-treated mice exhibit impaired muscle regeneration with inflammation and fat infiltration unlike wild-type mice

• diphtheria toxin treated mice subjected to an exercise routine exhibit a dramatic loss of myofibers, inflammation, fat infiltration, and loss of muscle mass unlike similarly treated wild-type mice

• transplantation of satellite cells expressing Tg(Pax7-EGFP)#Tajb fails to rescue muscle regeneration in diphtheria toxin-treated mice

immune system

myositis ( J:180899 )

• diphtheria toxin-treated mice exhibit modest cellular interstitial infiltration (primarily macrophagic) in muscles unlike in similarly treated wild-type mice

Genotype
MGI:5308742

cx3

• Allelic Composition: Pax7^{tm1.1(HBEGF,-EYFP)Mal}/Pax7⁺; Tg(Pax7-EGFP)15Tajb/0
• Genetic Background: involves: C57BL/6 * SJL/J

muscle

decreased satellite cell number ( J:180899 )

• mice treated with diphtheria toxin and cardiotoxin exhibit an almost total loss of GFP+ satellite cells

abnormal muscle regeneration ( J:180899 )

• mice treated with diphtheria and cardiotoxin exhibit impaired muscle regeneration compared with similarly treated wild-type mice