Phenotypes associated with this allele

• Allele Symbol: Mcph1^tm1.1Zqw
• Allele Name: targeted mutation 1.1, Zhao-Qi Wang
• Allele ID: MGI:5308745
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mcph1^tm1.1Zqw/Mcph1^tm1.1Zqw	Not Specified	MGI:5308754

Genotype
MGI:5308754

hm1

• Allelic Composition: Mcph1^tm1.1Zqw/Mcph1^tm1.1Zqw
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

ovary atrophy ( J:180706 )

♀

testicular atrophy ( J:180706 )

♂

infertility ( J:180706 )

nervous system

increased neuron apoptosis ( J:180706 )

• at E15.5, neuroprogenitors and newborn neurons exhibit increased apoptosis compared to in wild-type mice

abnormal neuron differentiation ( J:180706 )

• at E15.5, neuroprogenitors and newborn neurons exhibit increased apoptosis compared to in wild-type mice

• neocortex cells exhibit a higher cell-cycle exit index (CCEI) compared with wild-type cells

• neocortex cells exhibit abnormal mitotic division plane and division mode compared with wild-type cells

• centrosome maturation in neuroprogenitors lags behind the premature mitotic entry unlike in wild-type cells

• neuroprogenitors exhibit abnormal mitotic spindle, chromosome alignment and hypercondensed chromosomes compared with wild-type cells

• however, neuroprogenitors do not exhibit an increase in DNA double-strand breaks or chromosome breaks

abnormal neuronal precursor proliferation ( J:180706 )

• at E17.5, neuroprogenitor cell proliferation is decreased compared to in wild-type mice

abnormal brain development ( J:180706 )

• at E13.5, brain development is retarded compared to in wild-type mice

• mice exhibit defective neocortical development

abnormal cortical intermediate zone morphology ( J:180706 )

• decreased thickness

thin cortical plate ( J:180706 )

• at E15.5

decreased brain size ( J:180706 )

abnormal neocortex morphology ( J:180706 )

• mice exhibit defective neocortical development

thin cerebral cortex ( J:180706 )

• at E15.5

• decreased lateral and radial dimensions in newborn mice

cellular

abnormal chromosome morphology ( J:180706 )

• hypercondensed in neuroprogenitors

abnormal cell cycle ( J:180706 )

• neocortex cells exhibit a higher cell-cycle exit index (CCEI) compared with wild-type cells

abnormal mitosis ( J:180706 )

• neocortex cells exhibit abnormal mitotic division plane and division mode compared with wild-type cells

• centrosome maturation in neuroprogenitors lags behind the premature mitotic entry unlike in wild-type cells

• neuroprogenitors and mouse embryonic fibroblasts exhibit abnormal mitotic spindle and chromosome alignments compared with wild-type cells

abnormal mitotic spindle morphology ( J:180706 )

• in neuroprogenitors and mouse embryonic fibroblasts

increased neuron apoptosis ( J:180706 )

• at E15.5, neuroprogenitors and newborn neurons exhibit increased apoptosis compared to in wild-type mice

abnormal neuron differentiation ( J:180706 )

• at E15.5, neuroprogenitors and newborn neurons exhibit increased apoptosis compared to in wild-type mice

• neocortex cells exhibit a higher cell-cycle exit index (CCEI) compared with wild-type cells

• neocortex cells exhibit abnormal mitotic division plane and division mode compared with wild-type cells

• centrosome maturation in neuroprogenitors lags behind the premature mitotic entry unlike in wild-type cells

• neuroprogenitors exhibit abnormal mitotic spindle, chromosome alignment and hypercondensed chromosomes compared with wild-type cells

• however, neuroprogenitors do not exhibit an increase in DNA double-strand breaks or chromosome breaks

abnormal neuronal precursor proliferation ( J:180706 )

• at E17.5, neuroprogenitor cell proliferation is decreased compared to in wild-type mice

endocrine/exocrine glands

ovary atrophy ( J:180706 )

♀

testicular atrophy ( J:180706 )

♂

growth/size/body

microcephaly ( J:180706 )