Analysis Tools|
Allele Symbol Allele Name Allele ID |
Pitx2tm1.1Dmm targeted mutation 1.1, Donna M Martin MGI:5308807 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• abdominal viscera defects similar to in Pitx2tm2Sac homozygotes
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• distal turning defect similar to in Pitx2tm2Sac homozygotes
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• similar to in Pitx2tm2Sac homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• abdominal and abdominal viscera defects similar to in Pitx2tm2Sac homozygotes
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• distal turning defect similar to in Pitx2tm2Sac homozygotes
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• mice lack migration of subthalamic neurons and recruitment of their projections into an expanded mammillotegmental tract
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• mice lack migration of subthalamic neurons and recruitment of their projections into an expanded mammillotegmental tract
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• similar to in Pitx2tm2Sac homozygotes
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• medially displaced
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• severe
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• mice lack migration of subthalamic neurons and recruitment of their projections into an expanded mammillotegmental tract
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• severe
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• severe
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mammillothalamic tract fibers are truncated or severely diminished compared to in control mice
• PAX6+ cells at the principal mammillary tract-mammillothalamic tract bifurcation are reduced compared to in control mice
• however, mice exhibit intact principal mammillary and mammillotegmental projections
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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