Phenotypes associated with this allele

• Allele Symbol: Bst2^tm1.1Bsz
• Allele Name: targeted mutation 1.1, Paul Bieniasz
• Allele ID: MGI:5308812
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bst2^tm1.1Bsz/Bst2^tm1.1Bsz	involves: C57BL/6	MGI:5308856

Genotype
MGI:5308856

hm1

• Allelic Composition: Bst2^tm1.1Bsz/Bst2^tm1.1Bsz
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

enlarged spleen ( J:180252 )

• exacerbated in mice infected with murine AIDS virus (LP-BM5 strain of Mo-MLV)

enlarged lymph nodes ( J:180252 )

• exacerbated in mice infected with murine AIDS virus (LP-BM5 strain of Mo-MLV)

increased susceptibility to Retroviridae infection ( J:180252 )

• pIpC-treated mice exhibit increased Mo-MLV plasma viremia compared with wild-type mice

• mice infected with murine AIDS virus (LP-BM5 strain of Mo-MLV) exhibit increased viremia and exacerbated disease with increased splenomegaly and lymphadenopathy compared with wild-type mice

• however, mice exhibit normal response to Mo-MLV infection

cellular

abnormal cell physiology ( J:180252 )

• IFNalpha-treated mouse embryonic fibroblasts exhibit reduced antiretroviral activity as determined by Moloney murine leukemia virus (Mo-MLV) replication compared with wild-type cells

hematopoietic system

enlarged spleen ( J:180252 )

• exacerbated in mice infected with murine AIDS virus (LP-BM5 strain of Mo-MLV)

growth/size/body

enlarged spleen ( J:180252 )

• exacerbated in mice infected with murine AIDS virus (LP-BM5 strain of Mo-MLV)