Analysis Tools
mortality/aging
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• slightly fewer neonates are observed than expected
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embryo
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• maternal lacunae are dilated and/or more frequent with abnormal blood stasis compared to in wild-type mice
• mice exhibit a 5-fold increase in area of maternal lacunae compared with wild-type mice
• labyrinth layer architecture is disrupted by blood sinuses that are enlarged and extend from the spongiotrophoblast through the entire labyrinthine zona as a continuous blood pool
• by late gestational stages, placental labyrinth shows signs of degradation with breaks and vacuolization
• late gestation mice exhibit ultrastructural defects in the labyrinth
• however, mice exhibit normal the fetal placental labyrinth and no increase in placental apoptosis
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• moderate at E11.5 to E15.5
• clear at E16.5 to E18.5
• at E17.5, maternal blood lacunae is dilated with extremely thin walls about to rupture
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• formation of the syncytiotrophoblast layer II is impaired
• however, layer I forms normally
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growth/size/body
cardiovascular system
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• moderate at E11.5 to E15.5
• clear at E16.5 to E18.5
• at E17.5, maternal blood lacunae is dilated with extremely thin walls about to rupture
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