All Phenotypes Ctnnb1<tm3Kba> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ctnnb1^tm3Kba
targeted mutation 3, Konrad Basler
MGI:5308947

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ctnnb1^tm3Kba/Ctnnb1^tm3Kba	involves: 129S6/SvEvTac * C57BL/6	MGI:5308950
cn2	Ctnnb1^tm2Kem/Ctnnb1^tm3Kba H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129 * C57BL/6 * CBA/J	MGI:5308953
cn3	Ctnnb1^tm2Kem/Ctnnb1^tm3Kba Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129 * C57BL/6 * CBA/J	MGI:5308956

Allelic Composition	Ctnnb1^tm3Kba/Ctnnb1^tm3Kba
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^tm3Kba mutation (0 available); any Ctnnb1 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:178971 )

• total failure of embryonic development at E7.5

embryo

abnormal gastrulation ( J:178971 )

• strong defects in gastrulation are visible at E7.5

• total failure of embryonic development at E7.5

absent mesoderm ( J:178971 )

Allelic Composition	Ctnnb1^tm2Kem/Ctnnb1^tm3Kba H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129 * C57BL/6 * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^tm2Kem mutation (1 available); any Ctnnb1 mutation (49 available)
Ctnnb1^tm3Kba mutation (0 available); any Ctnnb1 mutation (49 available)
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron differentiation ( J:178971 )

• differentiation of sensory neurons in the neural tube is defective

abnormal midbrain morphology ( J:178971 )

• milder defects than in conditional mutant mice homozygous for Ctnnb1^tm2Kem at E12.5

craniofacial

abnormal craniofacial morphology ( J:178971 )

• milder defects than in conditional mutant mice homozygous for Ctnnb1^tm2Kem at E12.5

embryo

embryo phenotype ( J:178971 )

N	• apical neural tube morphology is not disrupted at E12.5

cellular

abnormal neuron differentiation ( J:178971 )

• differentiation of sensory neurons in the neural tube is defective

Allelic Composition	Ctnnb1^tm2Kem/Ctnnb1^tm3Kba Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129 * C57BL/6 * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^tm2Kem mutation (1 available); any Ctnnb1 mutation (49 available)
Ctnnb1^tm3Kba mutation (0 available); any Ctnnb1 mutation (49 available)
Gt(ROSA)26Sor^tm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (993 available)
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebellum development ( J:178971 )

• not developed at E10.5

absent midbrain-hindbrain boundary ( J:178971 )

• absent at E10.5

craniofacial

abnormal craniofacial bone morphology ( J:178971 )

• hypoplastic and malformed

skeleton

abnormal craniofacial bone morphology ( J:178971 )

• hypoplastic and malformed

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