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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Katnal11H
ENU mutation 1, Harwell
MGI:5309172
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Katnal11H/Katnal11H involves: C3H/HeH * C57BL/6J MGI:5427980


Genotype
MGI:5427980
hm1
Allelic
Composition		 Katnal11H/Katnal11H
Genetic
Background		 involves: C3H/HeH * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Katnal11H mutation (1 available); any Katnal1 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Katnal11H/Katnal11H mice show disruption of the seminiferous epithelium associated with a reduction in numbers of post-meiotic germ cells

reproductive system
abnormal seminiferous tubule epithelium morphology ( J:185195 )
• severely disrupted at 70 days of age
abnormal Sertoli cell morphology ( J:185195 )
• evidence of vacuolation is seen at 70 days of age
• cells contain fewer stable microtubules at 22 days of age
small seminiferous tubules ( J:185195 )
• reduced diameter at 35 days of age
decreased testis weight ( J:185195 )
• first observed at 35 days of age
abnormal spermatogenesis ( J:185195 )
• the caput and corpus epididymides contain exfoliated immature germ cells indicating premature exfoliation of spermatids from the seminiferous epithelium
oligozoospermia ( J:185195 )
• decrease in the number of recognizable spermatozoa in the epididymal lumen
decreased spermatid number ( J:185195 )
• decrease in the number of spermatids at 22, 35 and 70 days of age
decreased elongated spermatid number ( J:185195 )
• decrease in the numbers of elongated spermatids at 70 days of age
male infertility ( J:185195 )
• all males are infertile

endocrine/exocrine glands
abnormal seminiferous tubule epithelium morphology ( J:185195 )
• severely disrupted at 70 days of age
abnormal Sertoli cell morphology ( J:185195 )
• evidence of vacuolation is seen at 70 days of age
• cells contain fewer stable microtubules at 22 days of age
small seminiferous tubules ( J:185195 )
• reduced diameter at 35 days of age
decreased testis weight ( J:185195 )
• first observed at 35 days of age

cellular
oligozoospermia ( J:185195 )
• decrease in the number of recognizable spermatozoa in the epididymal lumen
decreased spermatid number ( J:185195 )
• decrease in the number of spermatids at 22, 35 and 70 days of age
decreased elongated spermatid number ( J:185195 )
• decrease in the numbers of elongated spermatids at 70 days of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory