All Phenotypes Trap1a<tm1.1Jvde> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Trap1a^tm1.1Jvde
targeted mutation 1.1, Benoit Van den Eynde
MGI:5309174

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	H2^d/H2^d Trap1a^tm1.1Jvde/Trap1a^tm1.1Jvde	involves: 129 * BALB/cJ * C57BL/10 * DBA/2	MGI:5310746
cx2	H2^d/H2^d Trap1a^tm1.1Jvde/Y	involves: 129 * BALB/cJ * C57BL/10 * DBA/2	MGI:5310747
cx3	H2^d/H2^d Tg(TcraP1.5,TcrbP1.5)29Amsv/0 Trap1a^tm1.1Jvde/Y	involves: 129 * BALB/cJ * C57BL/10 * DBA/2	MGI:5310748

Allelic Composition	H2^d/H2^d Trap1a^tm1.1Jvde/Trap1a^tm1.1Jvde
Genetic Background	involves: 129 * BALB/cJ * C57BL/10 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^d mutation (23 available); any H2 mutation (282 available)
Trap1a^tm1.1Jvde mutation (0 available); any Trap1a mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:180807 )

N	• mice are fertile

Allelic Composition	H2^d/H2^d Trap1a^tm1.1Jvde/Y
Genetic Background	involves: 129 * BALB/cJ * C57BL/10 * DBA/2

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:180807 )

• mice exhibit spontaneous rejection of P815 tumors and increased survival compared with wild-type mice

reproductive system

reproductive system phenotype ( J:180807 )

N	• mice are fertile

immune system

abnormal CD8-positive, alpha-beta T cell physiology ( J:180807 )

• P1A35-43-specific CD8 T lymphocytes exhibit increased functional avidity compared with wild-type cells

abnormal immune tolerance ( J:180807 )

• mice exhibit increased immunogenic response towards P1A35-43 compared with wild-type mice

neoplasm

tumor regression ( J:180807 )

• mice exhibit spontaneous rejection of P815 tumors and increased survival compared with wild-type mice

hematopoietic system

abnormal CD8-positive, alpha-beta T cell physiology ( J:180807 )

• P1A35-43-specific CD8 T lymphocytes exhibit increased functional avidity compared with wild-type cells

Allelic Composition	H2^d/H2^d Tg(TcraP1.5,TcrbP1.5)29Amsv/0 Trap1a^tm1.1Jvde/Y
Genetic Background	involves: 129 * BALB/cJ * C57BL/10 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^d mutation (23 available); any H2 mutation (282 available)
Tg(TcraP1.5,TcrbP1.5)29Amsv mutation (0 available)
Trap1a^tm1.1Jvde mutation (0 available); any Trap1a mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell clonal deletion ( J:180807 )

• T lymphocytes expressing the transgene are negatively selected in the thymus and strongly reduced in the periphery

hematopoietic system

abnormal T cell clonal deletion ( J:180807 )

• T lymphocytes expressing the transgene are negatively selected in the thymus and strongly reduced in the periphery

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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