Phenotypes associated with this allele

• Allele Symbol: Igf2^tm4Wrk
• Allele Name: targeted mutation 4, Wolf Reik
• Allele ID: MGI:5309176
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Igf2^tm4Wrk/Igf2^+	involves: 129P2/OlaHsd * C57BL/6	MGI:5310734

Genotype
MGI:5310734

ht1

• Allelic Composition: Igf2^tm4Wrk/Igf2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal imprinting ( J:169366 )

• maternal transmission of the repressor binding site-disrupted allele results in the loss of Igf2 imprinting (i.e. reactivation of the normally silent maternal allele) in mesodermal tissues; the degree of reactivation was not fully characterised but is observed (by RT-PCR) in tissues such as lung and heart.

• paternal transmission of the disrupted repressor binding site results in down-regulation of the placental-specific Igf2 transcript P0.

growth/size/body

decreased birth weight ( J:169366 )

• the birth weight of pups inheriting the floxed neo^r-disrupted repressor binding site allele paternally is ~24% that of wild-type neonates.

prenatal growth retardation ( J:169366 )

• paternal transmission of the neo^r-in repressor binding site disruption results in intra-uterine growth restriction (IUGR).