Analysis Tools
immune system
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• almost complete loss of LPS induced increased in TNF levels
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• failure of LPS induced secretion in bone marrow?derived macrophages
• however, LPS induced increases in expression are normal and full length protein accumulates on the plasma membrane indicating a defect in shedding of the protein
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integument
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• paws exhibit thinning of the epidermis
• however, no difference in the thickness of the back skin is seen
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homeostasis/metabolism
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• almost complete loss of LPS induced increased in TNF levels
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limbs/digits/tail
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• forepaws and hind paws show thinning of the footpads and show pallor and translucency, lacking the normal thickening and hyperpigmentation of the footpad
• mice show reduced cell proliferation in the paws
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