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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slc6a3tm1.1Jaja
targeted mutation 1.1, Jonathan A Javitch
MGI:5310749
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Slc6a3tm1.1Jaja/Slc6a3tm1.1Jaja B6.129-Slc6a3tm1.1Jaja MGI:5310793


Genotype
MGI:5310793
hm1
Allelic
Composition		 Slc6a3tm1.1Jaja/Slc6a3tm1.1Jaja
Genetic
Background		 B6.129-Slc6a3tm1.1Jaja
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc6a3tm1.1Jaja mutation (0 available); any Slc6a3 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:180517 )
N
• mice exhibit normal survival rate

reproductive system
reproductive system phenotype ( J:180517 )
N
• mice exhibit normal lactation

nervous system
decreased susceptibility to dopaminergic neuron neurotoxicity ( J:180517 )
• mice are resistant to paraquat-induced dopamine neuron neurotoxicity but decreased dopamine levels compared with wild-type mice

homeostasis/metabolism
decreased susceptibility to dopaminergic neuron neurotoxicity ( J:180517 )
• mice are resistant to paraquat-induced dopamine neuron neurotoxicity but decreased dopamine levels compared with wild-type mice
decreased dopamine level ( J:180517 )
• in paraquat-treated mice

cellular
decreased susceptibility to dopaminergic neuron neurotoxicity ( J:180517 )
• mice are resistant to paraquat-induced dopamine neuron neurotoxicity but decreased dopamine levels compared with wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory