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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Panx2tm1.1Mony
targeted mutation 1.1, Hannah Monyer
MGI:5310802
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Panx2tm1.1Mony/Panx2tm1.1Mony involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5311016
cx2
 		Panx1tm1.1Fama/Panx1tm1.1Fama
Panx2tm1.1Mony/Panx2tm1.1Mony 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5311017
cx3
 		Panx1tm1.1Fama/Panx1+
Panx2tm1.1Mony/Panx2+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5311018


Genotype
MGI:5311016
hm1
Allelic
Composition		 Panx2tm1.1Mony/Panx2tm1.1Mony
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Panx2tm1.1Mony mutation (0 available); any Panx2 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased susceptibility to ischemic brain injury ( J:180516 )
• in a stroke model using middle cerebral artery occlusion, mice exhibit decreased neurological deficits (latency to move) compared with wild-type mice
• however, infarct size is normal

nervous system
decreased susceptibility to ischemic brain injury ( J:180516 )
• in a stroke model using middle cerebral artery occlusion, mice exhibit decreased neurological deficits (latency to move) compared with wild-type mice
• however, infarct size is normal




Genotype
MGI:5311017
cx2
Allelic
Composition		 Panx1tm1.1Fama/Panx1tm1.1Fama
Panx2tm1.1Mony/Panx2tm1.1Mony
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Panx1tm1.1Fama mutation (1 available); any Panx1 mutation (38 available)
Panx2tm1.1Mony mutation (0 available); any Panx2 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Panx1tm1.1Fama/Panx1tm1.1Fama Panx2tm1.1Mony/Panx2tm1.1Mony mice are protected in a stroke model

nervous system
decreased susceptibility to ischemic brain injury ( J:180516 )
• in a stroke model using middle cerebral artery occlusion, mice exhibit decreased neurological deficits (right turns and latency to move) and infarct volume size compared with wild-type mice
• however, mice exhibit normal production of mature IL1B in cerebral ischemia
abnormal channel response ( J:180516 )
• neuron dye release to measure channel function is completely blocked unlike in wild-type cells
• however, mice exhibit normal channel function in astrocytes and cortical spreading depolarization

homeostasis/metabolism
decreased susceptibility to ischemic brain injury ( J:180516 )
• in a stroke model using middle cerebral artery occlusion, mice exhibit decreased neurological deficits (right turns and latency to move) and infarct volume size compared with wild-type mice
• however, mice exhibit normal production of mature IL1B in cerebral ischemia




Genotype
MGI:5311018
cx3
Allelic
Composition		 Panx1tm1.1Fama/Panx1+
Panx2tm1.1Mony/Panx2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Panx1tm1.1Fama mutation (1 available); any Panx1 mutation (38 available)
Panx2tm1.1Mony mutation (0 available); any Panx2 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal channel response ( J:180516 )
• neuron dye release to measure channel function is slightly decreased compared to in wild-type cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory