Analysis Tools|
Allele Symbol Allele Name Allele ID |
Gt(ROSA)26Sortm3(Runx2)Flng targeted mutation 3, Fanxin Long MGI:5311032 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the nonhypertrophic chondrocyte zone in the tibia is reduced to a greater extent than in Ihhtm1Amc homozygotes
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• hypertrophic chondrocytes exhibit accelerated progression from early stage to late stage hypertrophy compared with control mice
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• thin bone collar
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• impaired
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• impaired
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• impaired
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• unlike Runx2tm1Mjo homozygotes, mice exhibit normal cartilage, bone collar, and marrow and restored osteoblast differentiation and cartilage hypertrophy
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• at E18.5, bone formation defects observed in Runx2tm1Mjo homozygotes are partially recovered in the endochondrial skeleton but not the skull
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• unlike Runx2tm1Mjo homozygotes, mice exhibit normal bone collar
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• like Runx2tm1Mjo homozygotes, mice lack a marrow cavity
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• at E18.5, bone formation defects observed in Runx2tm1Mjo homozygotes are partially recovered in the endochondrial skeleton but not the skull
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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