Analysis Tools
mortality/aging
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• compared with controls that die within 20 weeks after infection with Leishmania major, mutants are still alive 6 months after infection
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immune system
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• 2 months after Leishmania major infection, lymph nodes and spleens contain more TH1 and fewer TH2 cells than controls
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• 2 months after Leishmania major infection, lymph nodes and spleens contain more TH1 and fewer TH2 cells than controls
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• lymph node CD4+ T cells from LACK immunized mice do not exhibit proliferation or cytokine secretion when incubated with LACK peptide, indicating that both TH1 and TH2 responses are tolerated unlike controls which show strong proliferation and cytokine secretion
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• tolerant mutants develop a TH1-dominated immune response, with CD4+ T cells secreting more IFN-gamma and less IL-4 in response to SLA than controls eight weeks after Leishmania major infection
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• mutants exhibit reduced TH2 responses after infection with Leishmania major compared to control
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• mutants infected with Leishmania major are still alive 6 months after infection compared to controls that die within 20 weeks after infection, and show tolerance to the LACK antigen
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• compared with controls that die within 20 weeks after infection with Leishmania major, mutants are still alive 6 months after infection
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hematopoietic system
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• 2 months after Leishmania major infection, lymph nodes and spleens contain more TH1 and fewer TH2 cells than controls
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• 2 months after Leishmania major infection, lymph nodes and spleens contain more TH1 and fewer TH2 cells than controls
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• tolerant mutants develop a TH1-dominated immune response, with CD4+ T cells secreting more IFN-gamma and less IL-4 in response to SLA than controls eight weeks after Leishmania major infection
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• mutants exhibit reduced TH2 responses after infection with Leishmania major compared to control
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