Phenotypes associated with this allele

• Allele Symbol: Tg(Neurod1-cre)RZ24Gsat
• Allele Name: transgene insertion RZ24, GENSAT Project at Rockefeller University
• Allele ID: MGI:5311739
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Chd7^tm2c(EUCOMM)Wtsi/Chd7^tm2c(EUCOMM)Wtsi Tg(Neurod1-cre)RZ24Gsat/0	involves: C57BL/6J * C57BL/6N * FVB/NTac	MGI:7518241
cn2	Chd7^tm2c(EUCOMM)Wtsi/Chd7^+ Tg(Neurod1-cre)RZ24Gsat/0	involves: C57BL/6J * C57BL/6N * FVB/NTac	MGI:7518243

Genotype
MGI:7518241

cn1

• Allelic Composition: Chd7^{tm2c(EUCOMM)Wtsi}/Chd7^{tm2c(EUCOMM)Wtsi}; Tg(Neurod1-cre)RZ24Gsat/0
• Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/NTac
• Cell Lines: EPD0019_1_D07

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:314588 )

• most show moderate hearing loss

nervous system

abnormal vestibulocochlear ganglion morphology ( J:314588 )

• rapid degeneration of neurons between P1 and P7, reducing numbers to 50% that of controls

neuron degeneration ( J:314588 )

• rapid degeneration of spiral ganglion neurons between P1 and P7, reducing numbers to 50% that of controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
CHARGE syndrome		DOID:0050834	OMIM:214800	J:314588

Genotype
MGI:7518243

cn2

• Allelic Composition: Chd7^{tm2c(EUCOMM)Wtsi}/Chd7⁺; Tg(Neurod1-cre)RZ24Gsat/0
• Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/NTac
• Cell Lines: EPD0019_1_D07

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:314588 )

• some show moderate hearing loss

nervous system

abnormal vestibulocochlear ganglion morphology ( J:314588 )

• slower degeneration of neurons between P1 and P21, reducing numbers to 50% that of controls by P21

neuron degeneration ( J:314588 )

• slower degeneration of spiral ganglion neurons between P1 and P21, reducing numbers to 50% that of controls by P21