Phenotypes associated with this allele

• Allele Symbol: Kdm8^tm1Tasu
• Allele Name: targeted mutation 1, Takeshi Suzuki
• Allele ID: MGI:5311829
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kdm8^tm1Tasu/Kdm8^tm1Tasu	involves: 129S4/SvJae * C57BL/6	MGI:5311836

Genotype
MGI:5311836

hm1

• Allelic Composition: Kdm8^tm1Tasu/Kdm8^tm1Tasu
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality ( J:181189 )

embryonic lethality during organogenesis, incomplete penetrance ( J:181189 )

• fewer than expected are found at E12.5

preweaning lethality, complete penetrance ( J:181189 )

• no mice are detected at P28

embryo

embryonic growth retardation ( J:181189 )

• most are severely growth retarded at E10.5

decreased embryo size ( J:181189 )

• embryos that are not severely growth retarded at E10.5 sill show reduced body size

cellular

decreased cell proliferation ( J:181189 )

• decreased proliferation of MEFs within 48 h of passage with cell numbers about 50% that of wild-type at 72 h after passage

• however, neither premature senescence nor increased apoptosis are detected

growth/size/body

embryonic growth retardation ( J:181189 )

• most are severely growth retarded at E10.5

decreased embryo size ( J:181189 )

• embryos that are not severely growth retarded at E10.5 sill show reduced body size