All Phenotypes Kdm8<tm1.2Tasu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kdm8^tm1.2Tasu
targeted mutation 1.2, Takeshi Suzuki
MGI:5311834

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kdm8^tm1.2Tasu/Kdm8^tm1.2Tasu	involves: 129S4/SvJae * C3H * C57BL/6	MGI:5311835
cx2	Cdkn1a^tm1Led/Cdkn1a^tm1Led Kdm8^tm1.2Tasu/Kdm8^tm1.2Tasu	involves: 129S4/SvJae * 129S6/SvEvTac * C3H * C57BL/6	MGI:5311838

Allelic Composition	Kdm8^tm1.2Tasu/Kdm8^tm1.2Tasu
Genetic Background	involves: 129S4/SvJae * C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm8^tm1.2Tasu mutation (0 available); any Kdm8 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:181189 )

• die around E11.0

embryo

absent vitelline blood vessels ( J:181189 )

• avascular yolk sacs at E10.5

incomplete embryo turning ( J:181189 )

• at E10.5

embryonic growth retardation ( J:181189 )

• slightly retarded at E7.5

• at E9.0 resemble wild-type embryos at E8.5

• severely growth retarded at E10.5

abnormal visceral yolk sac morphology ( J:181189 )

• clumps of red blood cells are visible at E10.5

cardiovascular system

absent vitelline blood vessels ( J:181189 )

• avascular yolk sacs at E10.5

growth/size/body

embryonic growth retardation ( J:181189 )

• slightly retarded at E7.5

• at E9.0 resemble wild-type embryos at E8.5

• severely growth retarded at E10.5

Allelic Composition	Cdkn1a^tm1Led/Cdkn1a^tm1Led Kdm8^tm1.2Tasu/Kdm8^tm1.2Tasu
Genetic Background	involves: 129S4/SvJae * 129S6/SvEvTac * C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1a^tm1Led mutation (1 available); any Cdkn1a mutation (63 available)
Kdm8^tm1.2Tasu mutation (0 available); any Kdm8 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:181189 )

embryo

absent vitelline blood vessels ( J:181189 )

• avascular yolk sacs at E10.5

incomplete embryo turning ( J:181189 )

• at E10.5

embryonic growth retardation ( J:181189 )

• severely growth retarded at E10.5

• however, embryos are slightly larger than littermates homozygous for Jmjd5^tm1.2Tasu alone

cardiovascular system

absent vitelline blood vessels ( J:181189 )

• avascular yolk sacs at E10.5

growth/size/body

embryonic growth retardation ( J:181189 )

• severely growth retarded at E10.5

• however, embryos are slightly larger than littermates homozygous for Jmjd5^tm1.2Tasu alone

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