All Phenotypes Pmm2<tm2.1Cknr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pmm2^tm2.1Cknr
targeted mutation 2.1, Christian Korner
MGI:5311938

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pmm2^tm2.1Cknr/Pmm2^tm2.1Cknr	involves: C57BL/6J	MGI:5311942
ht2	Pmm2^tm1.1Cknr/Pmm2^tm2.1Cknr	involves: C57BL/6J	MGI:5311941

Allelic Composition	Pmm2^tm2.1Cknr/Pmm2^tm2.1Cknr
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pmm2^tm2.1Cknr mutation (0 available); any Pmm2 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:180794 )

• mice die before E5.5

Allelic Composition	Pmm2^tm1.1Cknr/Pmm2^tm2.1Cknr
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pmm2^tm1.1Cknr mutation (0 available); any Pmm2 mutation (25 available)
Pmm2^tm2.1Cknr mutation (0 available); any Pmm2 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:180794 )

• mice die between E9.5 and E10.5

• however, mannose supplementation increases survival to beyond weaning even after post-weaning withdrawal of mannose supplementation

embryo

embryo phenotype ( J:180794 )

N	• supplementation of dam drinking water with mannose rescues embryogenesis

embryonic growth retardation ( J:180794 )

• between E7.5 and E9.5

abnormal embryonic tissue morphology ( J:180794 )

• at E10.0, mice exhibit degradation of embryonic structures (breakdown of myocardial tissues and reduction of compactness of neural epithelium and cephalic mesenchyme) unlike wild-type mice

abnormal head mesenchyme morphology ( J:180794 )

• reduction of compactness of cephalic mesenchyme at E10.0

abnormal embryonic neuroepithelium morphology ( J:180794 )

• reduction of compactness of neural epithelium at E10.0

abnormal extraembryonic tissue morphology ( J:180794 )

• massive hemorrhage within extraembryonic supporting structures at E10.0

abnormal trophoblast giant cell morphology ( J:180794 )

• potential loss of trophoblast giant cells

cardiovascular system

abnormal myocardium layer morphology ( J:180794 )

• breakdown at E10.0

hemorrhage ( J:180794 )

• massive hemorrhage within extraembryonic supporting structures at E10.0

cellular

abnormal cell physiology ( J:180794 )

• embryonic fibroblasts and whole embryos exhibit reduced general protein hypoglycosylation compared with wild-type cells and embryos

• however, supplementation with mannose restores glycosylation even after post-weaning withdrawal of mannose supplementation

growth/size/body

embryonic growth retardation ( J:180794 )

• between E7.5 and E9.5

abnormal head mesenchyme morphology ( J:180794 )

• reduction of compactness of cephalic mesenchyme at E10.0

decreased body length ( J:180794 )

• at E9.5

nervous system

abnormal embryonic neuroepithelium morphology ( J:180794 )

• reduction of compactness of neural epithelium at E10.0

muscle

abnormal myocardium layer morphology ( J:180794 )

• breakdown at E10.0

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