Phenotypes associated with this allele

• Allele Symbol: Il5^tm1Ktk
• Allele Name: targeted mutation 1, Kiyoshi Takatsu
• Allele ID: MGI:5312092
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il5^tm1Ktk/Il5^tm1Ktk	B6.129S4-Il5^tm1Ktk	MGI:5312102
ht2	Il5^tm1Ktk/Il5^+	B6.129S4-Il5^tm1Ktk	MGI:5312103

Genotype
MGI:5312102

hm1

• Allelic Composition: Il5^tm1Ktk/Il5^tm1Ktk
• Genetic Background: B6.129S4-Il5^tm1Ktk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B-1 B cell morphology ( J:180790 )

• small in size

decreased interleukin-5 secretion ( J:180790 )

• Th2 cells fail to produce IL5 in response to stimulation with PMA and ionomycin or anti-CD3 antibodies

neoplasm

increased metastatic potential ( J:180790 )

• mice injected with B16F10 melanoma cells exhibit increased nodule formation compared with wild-type mice

hematopoietic system

abnormal B-1 B cell morphology ( J:180790 )

• small in size

Genotype
MGI:5312103

ht2

• Allelic Composition: Il5^tm1Ktk/Il5⁺
• Genetic Background: B6.129S4-Il5^tm1Ktk

immune system

decreased interleukin-5 secretion ( J:180790 )

• in lung cells treated with IL33

• in Th2 cells treated with PMA and ionomycin or anti-CD3 antibodies