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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dcctm1.1Mehl
targeted mutation 1.1, Patrick Mehlen
MGI:5312257
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dcctm1.1Mehl/Dcctm1.1Mehl Not Specified MGI:5312325
cx2
 		Apctm1Rak/Apc+
Dcctm1.1Mehl/Dcctm1.1Mehl 		involves: 129P2/OlaHsd * C57BL/6 MGI:5312326


Genotype
MGI:5312325
hm1
Allelic
Composition		 Dcctm1.1Mehl/Dcctm1.1Mehl
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dcctm1.1Mehl mutation (0 available); any Dcc mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased fibroblast apoptosis ( J:181517 )
• MEFs in culture do not undergo apoptosis as readily as do controls when serum is removed
decreased enterocyte apoptosis ( J:181517 )
• less apoptosis in intestinal epithelium while cell proliferation and differentiation are normal

digestive/alimentary system
digestive/alimentary phenotype ( J:181517 )
N
• overall organization of the intestinal epithelium is unaffected
decreased enterocyte apoptosis ( J:181517 )
• less apoptosis in intestinal epithelium while cell proliferation and differentiation are normal
increased intestinal adenocarcinoma incidence ( J:181517 )
• spontaneous neoplastic transformations in 14.8% of homozygotes
• including adenocarcinomas
increased intestinal adenoma incidence ( J:181517 )
• spontaneous neoplastic transformations in 14.8% of homozygotes
• including adenomas

neoplasm
increased intestinal adenocarcinoma incidence ( J:181517 )
• spontaneous neoplastic transformations in 14.8% of homozygotes
• including adenocarcinomas
increased intestinal adenoma incidence ( J:181517 )
• spontaneous neoplastic transformations in 14.8% of homozygotes
• including adenomas




Genotype
MGI:5312326
cx2
Allelic
Composition		 Apctm1Rak/Apc+
Dcctm1.1Mehl/Dcctm1.1Mehl
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Rak mutation (1 available); any Apc mutation (158 available)
Dcctm1.1Mehl mutation (0 available); any Dcc mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased gastrointestinal tumor incidence ( J:181517 )
• all mice have tumors whereas 21.4% of heterozygous Apctm1Rak controls are tumor free
• tumor apoptosis rate in adenomas is reduced
increased intestinal adenocarcinoma incidence ( J:181517 )
• 100% have adenocarcenomas
increased metastatic potential ( J:181517 )
• 45.5% of tumors involve serosal invasion compared to 8% in controls
• micrometastatic lesions are found in the liver when serosal invasion occurs

digestive/alimentary system
increased gastrointestinal tumor incidence ( J:181517 )
• all mice have tumors whereas 21.4% of heterozygous Apctm1Rak controls are tumor free
• tumor apoptosis rate in adenomas is reduced
increased intestinal adenocarcinoma incidence ( J:181517 )
• 100% have adenocarcenomas




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory