Analysis Tools
endocrine/exocrine glands
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• soon after parturition, large T-antigen induced apoptosis of mammary epithelial (ME) cells outpaces their proliferation, leading to the elimination of the majority of ME cells
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• pregnant mice with this transgene exhibit almost normal mammary gland development until late pregnancy, when the ME cells begin to undergo both cell proliferation and apoptosis
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• pregnant mice with this transgene exhibit almost normal mammary gland development until late pregnancy, when the ME cells begin to undergo both cell proliferation and apoptosis
• soon after parturition, large T-antigen induced apoptosis of mammary epithelial (ME) cells outpaces their proliferation, leading to the elimination of the majority of ME cells
• loss of ME cells via apoptosis continues post-parturition, resulting in rapid decline in milk protein synthesis during the first days of lactation
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• mammary tumors occur in female mice with this transgene at a lower rate than the 6-12% frequency observed in small T-antigen transgenic females
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• loss of ME cells via apoptosis continues post-partum, resulting in rapid decline in milk protein synthesis during the first days of lactation
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integument
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• soon after parturition, large T-antigen induced apoptosis of mammary epithelial (ME) cells outpaces their proliferation, leading to the elimination of the majority of ME cells
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• pregnant mice with this transgene exhibit almost normal mammary gland development until late pregnancy, when the ME cells begin to undergo both cell proliferation and apoptosis
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• pregnant mice with this transgene exhibit almost normal mammary gland development until late pregnancy, when the ME cells begin to undergo both cell proliferation and apoptosis
• soon after parturition, large T-antigen induced apoptosis of mammary epithelial (ME) cells outpaces their proliferation, leading to the elimination of the majority of ME cells
• loss of ME cells via apoptosis continues post-parturition, resulting in rapid decline in milk protein synthesis during the first days of lactation
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• mammary tumors occur in female mice with this transgene at a lower rate than the 6-12% frequency observed in small T-antigen transgenic females
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• loss of ME cells via apoptosis continues post-partum, resulting in rapid decline in milk protein synthesis during the first days of lactation
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reproductive system
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• pregnant mice with this transgene exhibit almost normal mammary gland development until late pregnancy, when the ME cells begin to undergo both cell proliferation and apoptosis
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neoplasm
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• mammary tumors occur in female mice with this transgene at a lower rate than the 6-12% frequency observed in small T-antigen transgenic females
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