Phenotypes associated with this allele

• Allele Symbol: Mss51^{tm1(KOMP)Vlcg}
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:5312367
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mss51^tm1(KOMP)Vlcg/Mss51^tm1(KOMP)Vlcg	involves: C57BL/6NTac	MGI:6378219

Genotype
MGI:6378219

hm1

• Allelic Composition: Mss51^{tm1(KOMP)Vlcg}/Mss51^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NTac
• Cell Lines: 14311E-G5

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased aerobic running capacity ( J:280597 )

• young mice show a slight, but significant, running performance deficit in the treadmill-running test and middle-aged mice show a severe defect in running performance

• however, mice exhibit normal grip strength at young and middle ages

increased fasting circulating glucose level ( J:280597 )

• mice exhibit higher fasting blood-glucose levels than wild-type mice after 8 weeks of high-fat diet

increased circulating insulin level ( J:280597 )

• mice tend to exhibit higher plasma insulin levels than wild-type mice after 8 weeks of high-fat diet

• however, respiratory quotient is normal under both a normal diet and high-fat diet

impaired glucose tolerance ( J:280597 )

• aged, but not young, mice fed a normal diet exhibit severe glucose intolerance

• high-fat diet fed mice show severe glucose intolerance compared to wild-type mice

increased skeletal muscle glycogen level ( J:280597 )

• mice fed a high-fat diet show a high amount of glycogen accumulation in muscle

insulin resistance ( J:280597 )

• aged, but not young, mice fed a normal diet exhibit insulin resistance

• high-fat diet fed mice show severe insulin resistance compared to wild-type mice

liver/biliary system

increased liver weight ( J:280597 )

• mice fed a high-fat diet show a slightly higher liver weight than wild-type mice

hepatic steatosis ( J:280597 )

• high-fat diet fed mice show more severe hepatic steatosis compared to wild-type mice

muscle

abnormal muscle morphology ( J:280597 )

• muscle of young mice contains abnormal mitochondria with vacuoles and disrupted cristae

• muscle of middle aged mice contains abnormal organelle structures (vacuoles), including abnormal mitochondrial structure

increased skeletal muscle glycogen level ( J:280597 )

• mice fed a high-fat diet show a high amount of glycogen accumulation in muscle

adipose tissue

decreased inguinal fat pad weight ( J:280597 )

• mice fed a high-fat diet show lower inguinal fat weight

• however, no differences in body weight gain from wild-type is seen when fed a high-fat diet

behavior/neurological

decreased aerobic running capacity ( J:280597 )

• young mice show a slight, but significant, running performance deficit in the treadmill-running test and middle-aged mice show a severe defect in running performance

• however, mice exhibit normal grip strength at young and middle ages

cellular

abnormal mitochondrial morphology ( J:280597 )

• muscle contains abnormal mitochondria with vacuoles and disrupted cristae

• the number of atypical mitochondria is higher in plantaris muscle than in soleus muscle

• mice fed a high-fat diet show an abundance of abnormal mitochondria in plantaris muscle

• gastrocnemius muscle contains more abnormal mitochondria than soleus muscle, but the mtDNA/nuDNA ratio is not affected

increased mitochondrial DNA content ( J:280597 )

• the mtDNA/nuDNA ratio is increased in plantaris but not soleus muscle

abnormal mitochondrial crista morphology ( J:280597 )

• muscle contains mitochondria with disrupted cristae

abnormal mitochondrial shape ( J:280597 )

• myotubes exhibit elongated mitochondrial shapes

abnormal mitochondrial physiology ( J:280597 )

• myotubes show decreased basal respiration, proton leak, maximal respiration, and spare respiration capacity

growth/size/body

increased liver weight ( J:280597 )

• mice fed a high-fat diet show a slightly higher liver weight than wild-type mice