Analysis Tools
mortality/aging
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• homozygous mutant mice did not survive beyond P0
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growth/size/body
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• in histological preparations to reveal bone and cartilage (blue), it was shown that palatine and maxillary processes are extended to the midline in control tissues; in mutant mice, these processes are absent, exposing the vomer and presphenoid bones resulting in a complete cleft secondary palate
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• in histological preparations to reveal bone and cartilage (blue), it was shown that palatine and maxillary processes are extended to the midline in control tissues; in mutant mice, these processes are absent, exposing the vomer and presphenoid bones resulting in a complete cleft secondary palate
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• mutant mice show a deficiency in the process of palate fusion during development
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• shows medial coronal sections that reveal the palatal processes apposed but not fused at E14.5 in both WT and mutant mice, and already fused at E15.5 in the WT but not in the null mutant mouse
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• shows medial coronal sections that reveal the palatal processes apposed but not fused at E14.5 in both WT and mutant mice, and already fused at E15.5 in the WT but not in the null mutant mouse
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• newborn null mutant mice were slightly smaller than controls
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• embryos are slightly smaller from stage E15.5 onwards
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craniofacial
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• in histological preparations to reveal bone and cartilage (blue), it was shown that palatine and maxillary processes are extended to the midline in control tissues; in mutant mice, these processes are absent, exposing the vomer and presphenoid bones resulting in a complete cleft secondary palate
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• in histological preparations to reveal bone and cartilage (blue), it was shown that palatine and maxillary processes are extended to the midline in control tissues; in mutant mice, these processes are absent, exposing the vomer and presphenoid bones resulting in a complete cleft secondary palate
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• mutant mice show a deficiency in the process of palate fusion during development
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• shows medial coronal sections that reveal the palatal processes apposed but not fused at E14.5 in both WT and mutant mice, and already fused at E15.5 in the WT but not in the null mutant mouse
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• shows medial coronal sections that reveal the palatal processes apposed but not fused at E14.5 in both WT and mutant mice, and already fused at E15.5 in the WT but not in the null mutant mouse
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respiratory system
| N |
• mutant mice survive for up to 12 h after birth and do not appear cyanotic, suggesting an absence of respiratory distress
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• at E18.5 and P0, when embryonic mouse lung develops from canalicular stage to saccular stage, there appears that spaces in the mutant tissue are smaller than in the control tissue
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• terminal sacs of mutant mice were significantly smaller than those of controls at 18.5 dpc, and at P0
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digestive/alimentary system
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• in histological preparations to reveal bone and cartilage (blue), it was shown that palatine and maxillary processes are extended to the midline in control tissues; in mutant mice, these processes are absent, exposing the vomer and presphenoid bones resulting in a complete cleft secondary palate
|
|
• in histological preparations to reveal bone and cartilage (blue), it was shown that palatine and maxillary processes are extended to the midline in control tissues; in mutant mice, these processes are absent, exposing the vomer and presphenoid bones resulting in a complete cleft secondary palate
|
|
• mutant mice show a deficiency in the process of palate fusion during development
|
|
• shows medial coronal sections that reveal the palatal processes apposed but not fused at E14.5 in both WT and mutant mice, and already fused at E15.5 in the WT but not in the null mutant mouse
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• shows medial coronal sections that reveal the palatal processes apposed but not fused at E14.5 in both WT and mutant mice, and already fused at E15.5 in the WT but not in the null mutant mouse
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behavior/neurological
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• homozygous mutant mice failed to suckle
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skeleton
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• in histological preparations to reveal bone and cartilage (blue), it was shown that palatine and maxillary processes are extended to the midline in control tissues; in mutant mice, these processes are absent, exposing the vomer and presphenoid bones resulting in a complete cleft secondary palate
|
|
• in histological preparations to reveal bone and cartilage (blue), it was shown that palatine and maxillary processes are extended to the midline in control tissues; in mutant mice, these processes are absent, exposing the vomer and presphenoid bones resulting in a complete cleft secondary palate
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