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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dpysl2tm1.1Gosh
targeted mutation 1.1, Yoshio Goshima
MGI:5312892
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dpysl2tm1.1Gosh/Dpysl2tm1.1Gosh involves: 129P2/OlaHsd * C57BL/6J * FVB/N MGI:5312894
cx2
 		Crmp1tm1Pako/Crmp1tm1Pako
Dpysl2tm1.1Gosh/Dpysl2tm1.1Gosh
Tg(Thy1-YFP)HJrs/0 		involves: 129 * C57BL/6J * CBA * FVB/N MGI:5312896
cx3
 		Crmp1tm1Pako/Crmp1tm1Pako
Dpysl2tm1.1Gosh/Dpysl2tm1.1Gosh 		involves: 129 * C57BL/6J * FVB/N MGI:5312895
cx4
 		Dpysl2tm1.1Gosh/Dpysl2tm1.1Gosh
Tg(Thy1-YFP)HJrs/0 		involves: 129P2/OlaHsd * C57BL/6J * CBA * FVB/N MGI:5312898


Genotype
MGI:5312894
hm1
Allelic
Composition		 Dpysl2tm1.1Gosh/Dpysl2tm1.1Gosh
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dpysl2tm1.1Gosh mutation (0 available); any Dpysl2 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:180581 )
N
• gross cytoarchitecture of the cortical layer is essentially normal
abnormal dendrite morphology ( J:180581 )
• a slight but significant increase in the number of primary neurons displaying irregular curling dendritic elongation in culture




Genotype
MGI:5312896
cx2
Allelic
Composition		 Crmp1tm1Pako/Crmp1tm1Pako
Dpysl2tm1.1Gosh/Dpysl2tm1.1Gosh
Tg(Thy1-YFP)HJrs/0
Genetic
Background		 involves: 129 * C57BL/6J * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crmp1tm1Pako mutation (2 available); any Crmp1 mutation (45 available)
Dpysl2tm1.1Gosh mutation (0 available); any Dpysl2 mutation (34 available)
Tg(Thy1-YFP)HJrs mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cerebral cortex pyramidal cell morphology ( J:180581 )
• the basal dendrites of layer V pyramidal neurons grow to the apical side with curling and collaterals from apical trunks show disorientation and winding
abnormal dendrite morphology ( J:180581 )
• the basal dendrites of layer V pyramidal neurons grow to the apical side with curling and collaterals from apical trunks show disorientation and winding
• cortical neurons show an increase in the number of primary dendrites
• the highest number of dendrite crossings is found at about 40 um compared to 60-80 um in controls
• the basal dendritic field is further shifted to the apical part of the cell body and to the close part of cell body compared to mutant mice wild-type for Crmp1




Genotype
MGI:5312895
cx3
Allelic
Composition		 Crmp1tm1Pako/Crmp1tm1Pako
Dpysl2tm1.1Gosh/Dpysl2tm1.1Gosh
Genetic
Background		 involves: 129 * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crmp1tm1Pako mutation (2 available); any Crmp1 mutation (45 available)
Dpysl2tm1.1Gosh mutation (0 available); any Dpysl2 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:180581 )
N
• gross cytoarchitecture of the cortical layer is essentially normal
abnormal dendrite morphology ( J:180581 )
• significant increase in the number of primary neurons displaying irregular curling dendritic elongation in culture




Genotype
MGI:5312898
cx4
Allelic
Composition		 Dpysl2tm1.1Gosh/Dpysl2tm1.1Gosh
Tg(Thy1-YFP)HJrs/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dpysl2tm1.1Gosh mutation (0 available); any Dpysl2 mutation (34 available)
Tg(Thy1-YFP)HJrs mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal dendrite morphology ( J:180581 )
• cortical neurons show an increase in the number of primary dendrites
• the basal dendritic field is slightly shifted to the apical side of the cell body




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory