Phenotypes associated with this allele

• Allele Symbol: Mirc33^tm1Bdes
• Allele Name: targeted mutation 1, Bart de Stropper
• Allele ID: MGI:5312902
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mirc33^tm1Bdes/Mirc33^tm1Bdes	Not Specified	MGI:5312905

Genotype
MGI:5312905

hm1

• Allelic Composition: Mirc33^tm1Bdes/Mirc33^tm1Bdes
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal thymus involution ( J:180783 )

• premature involution starting after 4 weeks of age

• chemical castration, transplantation of wild-type bone marrow into mutants, or transplantation of mutant thymi into wild-type mice fails to reverse involution

• unlike in wild-type mice, a low dose of poly I:C induces rapid involution

immune system

abnormal thymus involution ( J:180783 )

• premature involution starting after 4 weeks of age

• chemical castration, transplantation of wild-type bone marrow into mutants, or transplantation of mutant thymi into wild-type mice fails to reverse involution

• unlike in wild-type mice, a low dose of poly I:C induces rapid involution

endocrine/exocrine glands

abnormal thymus involution ( J:180783 )

• premature involution starting after 4 weeks of age

• chemical castration, transplantation of wild-type bone marrow into mutants, or transplantation of mutant thymi into wild-type mice fails to reverse involution

• unlike in wild-type mice, a low dose of poly I:C induces rapid involution