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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Avil-icre/ERT2)AJwo
transgene insertion A, John N Wood
MGI:5312922
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Kcns1tm1.1Kcl/Kcns1tm1.1Kcl
Tg(Avil-icre/ERT2)AJwo/0 		involves: 129S7/SvEvBrd * C57BL/6J MGI:6357188
cn2
 		Adam23tm1.1Mejr/Adam23tm1.1Mejr
Tg(Avil-icre/ERT2)AJwo/0 		Not Specified MGI:7444422
tg3
 		Tg(Avil-icre/ERT2)AJwo/0 Not Specified MGI:5312934


Genotype
MGI:6357188
cn1
Allelic
Composition		 Kcns1tm1.1Kcl/Kcns1tm1.1Kcl
Tg(Avil-icre/ERT2)AJwo/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcns1tm1.1Kcl mutation (2 available); any Kcns1 mutation (29 available)
Tg(Avil-icre/ERT2)AJwo mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
enhanced coordination ( J:276188 )
• on a rotarod in tamoxifen-treated mice
abnormal mechanical nociception ( J:276188 )
• reduced threshold in tamoxifen-treated mice; more pronounced in female mice
• reduced threshold following neuropathic pain induced by nerve injury in tamoxifen-treated mice
• however, hot or cold thermal nociception is normal
hyperalgesia ( J:276188 )
• in response to mechanical pain following neuropathic pain induced by nerve injury in tamoxifen-treated mice
hyperresponsive to tactile stimuli ( J:276188 )
• reduced threshold in tamoxifen-treated mice; more pronounced in female mice
• however, hot or cold thermal nociception is normal
decreased thermal nociceptive threshold ( J:276188 )
• to innocuous and noxious cold temperatures pain following neuropathic pain induced by nerve injury in tamoxifen-treated mice
• however, hot thermal nociception in a neuropathic pain model is normal




Genotype
MGI:7444422
cn2
Allelic
Composition		 Adam23tm1.1Mejr/Adam23tm1.1Mejr
Tg(Avil-icre/ERT2)AJwo/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam23tm1.1Mejr mutation (0 available); any Adam23 mutation (63 available)
Tg(Avil-icre/ERT2)AJwo mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron morphology ( J:333962 )
• Kv1 channel complex protein disappear form the juxtaparanodal membrane between 10- and 29-weeks post-tamoxifen treatment




Genotype
MGI:5312934
tg3
Allelic
Composition		 Tg(Avil-icre/ERT2)AJwo/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Avil-icre/ERT2)AJwo mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:181671 )
N
• motor function in tamoxifen-treated mice is not significantly different from controls
• acute and imflammatory behavior in tamoxifen-treated mice is not different from controls




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory