Phenotypes associated with this allele

• Allele Symbol: Tgfb3^tm1.1Moaz
• Allele Name: targeted mutation 1.1, Mohamad Azhar
• Allele ID: MGI:5313416
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tgfb3^tm1Moaz/Tgfb3^tm1.1Moaz Tg(EIIa-cre)C5379Lmgd/0	involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * FVB/N	MGI:5313418

Genotype
MGI:5313418

cn1

• Allelic Composition: Tgfb3^tm1Moaz/Tgfb3^tm1.1Moaz; Tg(EIIa-cre)C5379Lmgd/0
• Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:181226 )

• although born at the expected ratio, homozyotes gasp, suckle poorly and die

respiratory system

respiratory distress ( J:181226 )

• gasping after birth

behavior/neurological

absent gastric milk in neonates ( J:181226 )

• little or no milk in pups' stomachs

abnormal suckling behavior ( J:181226 )

• suckle poorly

craniofacial

cleft palate ( J:181226 )

• complete or partial cleft palate in all E18.5 embryos and in new born pups

complete cleft palate ( J:181226 )

digestive/alimentary system

cleft palate ( J:181226 )

• complete or partial cleft palate in all E18.5 embryos and in new born pups

complete cleft palate ( J:181226 )

growth/size/body

cleft palate ( J:181226 )

• complete or partial cleft palate in all E18.5 embryos and in new born pups

complete cleft palate ( J:181226 )