Phenotypes associated with this allele

• Allele Symbol: Bcl2^tm1.1Sjk
• Allele Name: targeted mutation 1.1, Stanley Korsmeyer
• Allele ID: MGI:5313428
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Bcl2^tm1.1Sjk/Bcl2^tm1.1Sjk Tg(APPV717F)109Ili/0	involves: 129X1/SvJ * C57BL/6	MGI:6257027
cx2	Bcl2^tm1.1Sjk/Bcl2^tm1.1Sjk Tg(CAG-EGFP/Map1lc3b)53Nmz/0	involves: 129X1/SvJ * C57BL/6 * C57BL/6NCrj * SJL	MGI:5313437

Genotype
MGI:6257027

cx1

• Allelic Composition: Bcl2^tm1.1Sjk/Bcl2^tm1.1Sjk; Tg(APPV717F)109Ili/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:244104 )

• mice show a trend of exacerbated mortality compared to single Tg(APPV717F)109Ili expressing mice

Genotype
MGI:5313437

cx2

• Allelic Composition: Bcl2^tm1.1Sjk/Bcl2^tm1.1Sjk; Tg(CAG-EGFP/Map1lc3b)53Nmz/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6NCrj * SJL

homeostasis/metabolism

impaired exercise endurance ( J:181308 )

• decreased exercise endurance

impaired autophagy ( J:181308 )

• reduced in starved mouse embryonic fibroblasts and skeletal and cardiac muscles or skeletal muscles from exercised mice

• however, basal levels of autophagy are normal

increased circulating leptin level ( J:181308 )

• in mice fed a high-fat diet with no drop in levels following exercise unlike in wild-type mice

abnormal carbon dioxide production ( J:181308 )

• exercised mice fed a high-fat diet fail to exhibit an increase in carbon dioxide production unlike wild-type mice

abnormal oxygen consumption ( J:181308 )

• exercised mice fed a high-fat diet fail to exhibit an increase in oxygen consumption unlike wild-type mice

abnormal glucose homeostasis ( J:181308 )

• mice exhibit impaired exercise-induced increase in insulin sensitivity compared with wild-type mice

abnormal circulating glucose level ( J:181308 )

• exercised mice fail to exhibit a decrease in circulating glucose levels compared with wild-type mice

abnormal circulating insulin level ( J:181308 )

• exercised mice exhibit less of a reduction in plasma insulin levels compared with wild-type mice

abnormal glucose tolerance ( J:181308 )

• exercised mice fed a high-fat diet fail to exhibit protection from impaired glucose tolerance compared with wild-type mice

• however, mice fed standard chow exhibit normal glucose tolerance

abnormal circulating adiponectin level ( J:181308 )

• exercised mice fed a high-fat diet fail to exhibit an increase in adiponectin levels unlike in wild-type mice

abnormal cholesterol homeostasis ( J:181308 )

• exercised mice fed a high-fat diet exhibit less of a decrease in cholesterol levels compared with wild-type mice

abnormal triglyceride level ( J:181308 )

• exercised mice fed a high-fat diet exhibit less of a decrease in triglyceride levels compared with wild-type mice

abnormal basal metabolism ( J:181308 )

• exercised mice fed a high-fat diet fail to exhibit an increase in heat production unlike wild-type mice

cellular

impaired autophagy ( J:181308 )

• reduced in starved mouse embryonic fibroblasts and skeletal and cardiac muscles or skeletal muscles from exercised mice

• however, basal levels of autophagy are normal

decreased skeletal muscle cell glucose uptake ( J:181308 )

• decreased 14C-deoxyglucose uptake in soleus muscle during treadmill exercise

adipose tissue

abnormal percent body fat/body weight ( J:181308 )

• exercised mice fed a high-fat diet exhibit less of a decrease in percent fat mass compared with wild-type mice

muscle

muscle phenotype ( J:181308 )

N • baseline cardiac and skeletal muscle properties are normal

decreased skeletal muscle cell glucose uptake ( J:181308 )

• decreased 14C-deoxyglucose uptake in soleus muscle during treadmill exercise

behavior/neurological

impaired exercise endurance ( J:181308 )

• decreased exercise endurance