mortality/aging
• mice show a trend of exacerbated mortality compared to single Tg(APPV717F)109Ili expressing mice
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Allele Symbol Allele Name Allele ID |
Bcl2tm1.1Sjk targeted mutation 1.1, Stanley Korsmeyer MGI:5313428 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice show a trend of exacerbated mortality compared to single Tg(APPV717F)109Ili expressing mice
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• decreased exercise endurance
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• reduced in starved mouse embryonic fibroblasts and skeletal and cardiac muscles or skeletal muscles from exercised mice
• however, basal levels of autophagy are normal
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• in mice fed a high-fat diet with no drop in levels following exercise unlike in wild-type mice
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• exercised mice fed a high-fat diet fail to exhibit an increase in carbon dioxide production unlike wild-type mice
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• exercised mice fed a high-fat diet fail to exhibit an increase in oxygen consumption unlike wild-type mice
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• mice exhibit impaired exercise-induced increase in insulin sensitivity compared with wild-type mice
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• exercised mice fail to exhibit a decrease in circulating glucose levels compared with wild-type mice
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• exercised mice exhibit less of a reduction in plasma insulin levels compared with wild-type mice
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• exercised mice fed a high-fat diet fail to exhibit protection from impaired glucose tolerance compared with wild-type mice
• however, mice fed standard chow exhibit normal glucose tolerance
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• exercised mice fed a high-fat diet fail to exhibit an increase in adiponectin levels unlike in wild-type mice
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• exercised mice fed a high-fat diet exhibit less of a decrease in cholesterol levels compared with wild-type mice
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• exercised mice fed a high-fat diet exhibit less of a decrease in triglyceride levels compared with wild-type mice
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• exercised mice fed a high-fat diet fail to exhibit an increase in heat production unlike wild-type mice
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• reduced in starved mouse embryonic fibroblasts and skeletal and cardiac muscles or skeletal muscles from exercised mice
• however, basal levels of autophagy are normal
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• decreased 14C-deoxyglucose uptake in soleus muscle during treadmill exercise
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• exercised mice fed a high-fat diet exhibit less of a decrease in percent fat mass compared with wild-type mice
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N |
• baseline cardiac and skeletal muscle properties are normal
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• decreased 14C-deoxyglucose uptake in soleus muscle during treadmill exercise
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• decreased exercise endurance
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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