Phenotypes associated with this allele

• Allele Symbol: Prkg1^tm1.1Arte
• Allele Name: targeted mutation 1.1, TaconicArtemis
• Allele ID: MGI:5313455
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prkg1^tm1.1Arte/Prkg1^tm1.1Arte	C57BL/6-Prkg1^tm1.1Arte	MGI:5313462

Genotype
MGI:5313462

hm1

• Allelic Composition: Prkg1^tm1.1Arte/Prkg1^tm1.1Arte
• Genetic Background: C57BL/6-Prkg1^tm1.1Arte

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased cardiac output ( J:181180 )

• slightly depressed cardiac relative to controls with similar heart weights

increased systemic arterial blood pressure ( J:181180 )

• blood pressure increase induced by L-NAME is greater than in controls

increased mean systemic arterial blood pressure ( J:181180 )

increased systemic arterial diastolic blood pressure ( J:181180 )

increased systemic arterial systolic blood pressure ( J:181180 )

decreased vasodilation ( J:181180 )

• aortas are partially resistant to H2O2-induced relaxation

• 45% deficit in maximal dilatory response at high doses of H2O2

• marked reduction in H2O2 induced hyperpolarization of mesenteric vessels

• acetylcholine dependent relaxation of mesenteric vessels is attenuated

muscle

decreased vasodilation ( J:181180 )

• aortas are partially resistant to H2O2-induced relaxation

• 45% deficit in maximal dilatory response at high doses of H2O2

• marked reduction in H2O2 induced hyperpolarization of mesenteric vessels

• acetylcholine dependent relaxation of mesenteric vessels is attenuated