About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cigs2tm1.1Anse
targeted mutation 1.1, K Mark Ansel
MGI:5313809
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cigs2tm1.1Anse/Cigs2tm1.1Anse involves: BALB/cJ * C57BL/6 MGI:5314000
cx2
 		Cigs2tm1.1Anse/Cigs2+
Il4tm1(CD2)Mmrs/Il4+ 		involves: 129 * BALB/cJ * C57BL/6 MGI:5313999


Genotype
MGI:5314000
hm1
Allelic
Composition		 Cigs2tm1.1Anse/Cigs2tm1.1Anse
Genetic
Background		 involves: BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal class switch recombination ( J:181313 )
• IgE switching is abolished following exposure to ovalbumin
abnormal humoral immune response ( J:181313 )
• following exposure to ovalbumin, type 2 responses are reduced (pulmonary resistance, numbers of eosinophils and lymphocytes in bronchoalveolar lavage fluid and IgE switching) compared with wild-type mice
• mice exposed to Leishmania exhibit decreased IgE, decreased IgG1 and increased IgG2b compared with wild-type mice
• however, ovalbumin-exposed mice exhibit normal peribronchial and perivascular inflammatory infiltrates and mucus hypersecretion typical of allergic inflammation and normal footpad swelling and Leishmania-exposed mice exhibit normal parasite titer in response to
decreased IgE level ( J:181313 )
• following exposure to ovalbumin
decreased IgG1 level ( J:181313 )
• in response to Leishmania exposure
increased IgG2b level ( J:181313 )
• in response to Leishmania exposure
decreased interleukin-13 secretion ( J:181313 )
• in Th2 polarized CD4+ T cells
decreased interleukin-4 secretion ( J:181313 )
• in Th2 polarized CD4+ T cells
• in restimulated T cells in the draining popliteal lymph nodes of mice exposed to Leishmania
abnormal susceptibility to infection ( J:181313 )
• mice exposed to Leishmania exhibit decreased IgE, decreased IgG1 and increased IgG2b compared with wild-type mice
• however, mice exhibit normal footpad swelling and parasite titer

respiratory system
decreased airway resistance ( J:181313 )
• following exposure to ovalbumin

hematopoietic system
abnormal class switch recombination ( J:181313 )
• IgE switching is abolished following exposure to ovalbumin
decreased IgE level ( J:181313 )
• following exposure to ovalbumin
decreased IgG1 level ( J:181313 )
• in response to Leishmania exposure
increased IgG2b level ( J:181313 )
• in response to Leishmania exposure




Genotype
MGI:5313999
cx2
Allelic
Composition		 Cigs2tm1.1Anse/Cigs2+
Il4tm1(CD2)Mmrs/Il4+
Genetic
Background		 involves: 129 * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cigs2tm1.1Anse mutation (0 available); any Cigs2 mutation (0 available)
Il4tm1(CD2)Mmrs mutation (0 available); any Il4 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:181313 )
N
• following intraperitoneal injection of ovalbumin, mice exhibit normal IgG2b response compared with Il4tm1(CD2)Mmrs heterozygotes
• T cells and basophils exhibit normal Il13 production
decreased basophil cell number ( J:181313 )
• reduced CD2+ basophils from mice sensitized and challenged with ovalbumin to induce allergic airway inflammation
decreased IgE level ( J:181313 )
• following intraperitoneal injection of ovalbumin as in Il4tm1(CD2)Mmrs homozygotes
decreased IgG1 level ( J:181313 )
• following intraperitoneal injection of ovalbumin as in Il4tm1(CD2)Mmrs homozygotes
decreased interleukin-4 secretion ( J:181313 )
• in Th2 polarized CD4+ T cells compared with Il4tm1(CD2)Mmrs heterozygotes
• in parathymic lymph node and lung-draining mediastinal node T cells from mice injected with ovalbumin
• in T cells and basophils from mice sensitized and challenged with ovalbumin to induce allergic airway inflammation

hematopoietic system
decreased basophil cell number ( J:181313 )
• reduced CD2+ basophils from mice sensitized and challenged with ovalbumin to induce allergic airway inflammation
decreased IgE level ( J:181313 )
• following intraperitoneal injection of ovalbumin as in Il4tm1(CD2)Mmrs homozygotes
decreased IgG1 level ( J:181313 )
• following intraperitoneal injection of ovalbumin as in Il4tm1(CD2)Mmrs homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory