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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm10(Lmp1)Rsky
targeted mutation 10, Klaus Rajewsky
MGI:5314029
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+ involves: BALB/cJ MGI:5314102
cn2
 		Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+
Tcrbtm1Mom/Tcrb+
Tcrdtm1Mom/Tcrdtm1Mom
Cd19tm1(cre)Cgn/Cd19+ 		involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ MGI:5314090
cn3
 		Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+
Tcrbtm1Mom/Tcrbtm1Mom
Tcrdtm1Mom/Tcrdtm1Mom
Cd19tm1(cre)Cgn/Cd19+ 		involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ MGI:5314093
cn4
 		Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+
Cd19tm1(cre)Cgn/Cd19+ 		involves: 129P2/OlaHsd * BALB/cJ MGI:5314103
cn5
 		Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+
Klrk1tm1Dhr/Klrk1tm1Dhr
Cd19tm1(cre)Cgn/Cd19+ 		involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 MGI:5314085


Genotype
MGI:5314102
cn1
Allelic
Composition		 Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+
Genetic
Background		 involves: BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm10(Lmp1)Rsky mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased B cell proliferation ( J:181546 )
• B cells treated with TAT-cre proliferate in culture unlike wild-type cells
abnormal B cell morphology ( J:181546 )
• B cells treated with TAT-cre exhibit increased cell size compared with wild-type cells

hematopoietic system
increased B cell proliferation ( J:181546 )
• B cells treated with TAT-cre proliferate in culture unlike wild-type cells
abnormal B cell morphology ( J:181546 )
• B cells treated with TAT-cre exhibit increased cell size compared with wild-type cells

cellular
increased B cell proliferation ( J:181546 )
• B cells treated with TAT-cre proliferate in culture unlike wild-type cells




Genotype
MGI:5314090
cn2
Allelic
Composition		 Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+
Tcrbtm1Mom/Tcrb+
Tcrdtm1Mom/Tcrdtm1Mom
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Gt(ROSA)26Sortm10(Lmp1)Rsky mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Tcrbtm1Mom mutation (12 available); any Tcrb mutation (97 available)
Tcrdtm1Mom mutation (13 available); any Tcrd mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

immune system

hematopoietic system

growth/size/body
enlarged spleen ( J:181546 )




Genotype
MGI:5314093
cn3
Allelic
Composition		 Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+
Tcrbtm1Mom/Tcrbtm1Mom
Tcrdtm1Mom/Tcrdtm1Mom
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Gt(ROSA)26Sortm10(Lmp1)Rsky mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Tcrbtm1Mom mutation (12 available); any Tcrb mutation (97 available)
Tcrdtm1Mom mutation (13 available); any Tcrd mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

immune system

liver/biliary system
enlarged liver ( J:181546 )
• occasionally

neoplasm
increased B cell derived lymphoma incidence ( J:181546 )
• most tumors resemble diffuse large B cell lymphomas (in 6 of 9 mice)

hematopoietic system

growth/size/body
enlarged liver ( J:181546 )
• occasionally
enlarged spleen ( J:181546 )




Genotype
MGI:5314103
cn4
Allelic
Composition		 Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Gt(ROSA)26Sortm10(Lmp1)Rsky mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to induced morbidity/mortality ( J:181546 )
• 2 weeks after treatment with a cocktail of depleting antibodies (anti-CD4, anti-CD8 and anti-Thy1)

immune system
enlarged spleen ( J:181546 )
• 2 weeks after treatment with a cocktail of depleting antibodies (anti-CD4, anti-CD8 and anti-Thy1)
abnormal B cell differentiation ( J:181546 )
• impaired in the bone marrow
increased pro-B cell number ( J:181546 )
• at 6 to 12 weeks in the bone marrow
decreased B cell number ( J:181546 )
• at 6 to 12 weeks in the spleen and bone marrow
• absent CD19+Fas+ B cells at 8 to 11 weeks in the spleen
decreased mature B cell number ( J:181546 )
• at 6 to 12 weeks in the bone marrow
decreased pre-B cell number ( J:181546 )
• at 6 to 12 weeks in the bone marrow
increased B cell number ( J:181546 )
• at P8, mice exhibit an increase in CD19+ B cells in the spleen compared with control mice
increased CD4-positive, alpha-beta T cell number ( J:181546 )
• at P8, but not P3, in the spleen
• of activated T cells in the bone marrow at 6 to 12 weeks
increased CD8-positive, alpha-beta T cell number ( J:181546 )
• at P8, but not P3, in the spleen
• of activated T cells in the bone marrow at 6 to 12 weeks
abnormal immune system physiology ( J:181546 )
• after 2 weeks, mice treated with a cocktail of depleting antibodies (anti-CD4, anti-CD8 and anti-Thy1) exhibit splenomegaly and become terminally ill unlike control mice
increased B cell proliferation ( J:181546 )
• after 2 weeks, mice treated with a cocktail of depleting antibodies (anti-CD4, anti-CD8 and anti-Thy1) exhibit rapid expansion of Lmp1+ B cell blasts largely confined to peripheral lymphoid organs and the bone marrow with some infiltration into the liver and rarely into lungs and kidneys compared with control mice
• however, mice treated with one depleting antibodies (anti-CD4, anti-CD8, anti-Thy1 or anti-CD4 and anti-CD8) do not exhibit expansion of B cells
abnormal CD8-positive, alpha-beta T cell physiology ( J:181546 )
• the CD8+ compartment of the bone marrow of mice treated with a cocktail of depleting antibodies (anti-CD4, anti-CD8 and anti-Thy1) exhibit a 2-fold increase in cells expressing IFN-gamma, TNF-alpha, IL4 and IL17

hematopoietic system
increased B cell proliferation ( J:181546 )
• after 2 weeks, mice treated with a cocktail of depleting antibodies (anti-CD4, anti-CD8 and anti-Thy1) exhibit rapid expansion of Lmp1+ B cell blasts largely confined to peripheral lymphoid organs and the bone marrow with some infiltration into the liver and rarely into lungs and kidneys compared with control mice
• however, mice treated with one depleting antibodies (anti-CD4, anti-CD8, anti-Thy1 or anti-CD4 and anti-CD8) do not exhibit expansion of B cells
enlarged spleen ( J:181546 )
• 2 weeks after treatment with a cocktail of depleting antibodies (anti-CD4, anti-CD8 and anti-Thy1)
abnormal B cell differentiation ( J:181546 )
• impaired in the bone marrow
increased pro-B cell number ( J:181546 )
• at 6 to 12 weeks in the bone marrow
decreased B cell number ( J:181546 )
• at 6 to 12 weeks in the spleen and bone marrow
• absent CD19+Fas+ B cells at 8 to 11 weeks in the spleen
decreased mature B cell number ( J:181546 )
• at 6 to 12 weeks in the bone marrow
decreased pre-B cell number ( J:181546 )
• at 6 to 12 weeks in the bone marrow
increased B cell number ( J:181546 )
• at P8, mice exhibit an increase in CD19+ B cells in the spleen compared with control mice
increased CD4-positive, alpha-beta T cell number ( J:181546 )
• at P8, but not P3, in the spleen
• of activated T cells in the bone marrow at 6 to 12 weeks
increased CD8-positive, alpha-beta T cell number ( J:181546 )
• at P8, but not P3, in the spleen
• of activated T cells in the bone marrow at 6 to 12 weeks
abnormal CD8-positive, alpha-beta T cell physiology ( J:181546 )
• the CD8+ compartment of the bone marrow of mice treated with a cocktail of depleting antibodies (anti-CD4, anti-CD8 and anti-Thy1) exhibit a 2-fold increase in cells expressing IFN-gamma, TNF-alpha, IL4 and IL17

cellular
increased B cell proliferation ( J:181546 )
• after 2 weeks, mice treated with a cocktail of depleting antibodies (anti-CD4, anti-CD8 and anti-Thy1) exhibit rapid expansion of Lmp1+ B cell blasts largely confined to peripheral lymphoid organs and the bone marrow with some infiltration into the liver and rarely into lungs and kidneys compared with control mice
• however, mice treated with one depleting antibodies (anti-CD4, anti-CD8, anti-Thy1 or anti-CD4 and anti-CD8) do not exhibit expansion of B cells

growth/size/body
enlarged spleen ( J:181546 )
• 2 weeks after treatment with a cocktail of depleting antibodies (anti-CD4, anti-CD8 and anti-Thy1)




Genotype
MGI:5314085
cn5
Allelic
Composition		 Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+
Klrk1tm1Dhr/Klrk1tm1Dhr
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Gt(ROSA)26Sortm10(Lmp1)Rsky mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Klrk1tm1Dhr mutation (3 available); any Klrk1 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:181546 )
N
• mice are protected from Lmp1-driven lymphomagenesis




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory