All Phenotypes Gt(ROSA)26Sor<tm11(Lmp1)Rsky> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^{tm11(Lmp1)Rsky}/Gt(ROSA)26Sor⁺	involves: C57BL/6	MGI:5314101
cn2	Gt(ROSA)26Sor^{tm11(Lmp1)Rsky}/Gt(ROSA)26Sor⁺ Tcrb^tm1Mom/Tcrb⁺ Tcrd^tm1Mom/Tcrd^tm1Mom Cd19^tm1(cre)Cgn/Cd19⁺	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:5314091
cn3	Gt(ROSA)26Sor^{tm11(Lmp1)Rsky}/Gt(ROSA)26Sor⁺ Tcrb^tm1Mom/Tcrb^tm1Mom Tcrd^tm1Mom/Tcrd^tm1Mom Cd19^tm1(cre)Cgn/Cd19⁺	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:5314096
cn4	Gt(ROSA)26Sor^{tm11(Lmp1)Rsky}/Gt(ROSA)26Sor⁺ Klrk1^tm1Dhr/Klrk1^tm1Dhr Cd19^tm1(cre)Cgn/Cd19⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:5314087
cn5	Gt(ROSA)26Sor^{tm11(Lmp1)Rsky}/Gt(ROSA)26Sor⁺ Cd19^tm1(cre)Cgn/Cd19⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:5314104
cn6	Gt(ROSA)26Sor^{tm11(Lmp1)Rsky}/Gt(ROSA)26Sor⁺ Cd19^{tm1(cre/ERT2)Rsky}/Cd19⁺	involves: 129P2/OlaHsd * C57BL/6J	MGI:5614487

Allelic Composition	Gt(ROSA)26Sor^{tm11(Lmp1)Rsky}/Gt(ROSA)26Sor⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm11(Lmp1)Rsky} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased B cell proliferation ( J:181546 )

• B cells treated with TAT-cre proliferate in culture unlike wild-type cells

abnormal B cell morphology ( J:181546 )

• B cells treated with TAT-cre exhibit increased cell size compared with wild-type cells

hematopoietic system

increased B cell proliferation ( J:181546 )

• B cells treated with TAT-cre proliferate in culture unlike wild-type cells

abnormal B cell morphology ( J:181546 )

• B cells treated with TAT-cre exhibit increased cell size compared with wild-type cells

cellular

increased B cell proliferation ( J:181546 )

• B cells treated with TAT-cre proliferate in culture unlike wild-type cells

Allelic Composition	Gt(ROSA)26Sor^{tm11(Lmp1)Rsky}/Gt(ROSA)26Sor⁺ Tcrb^tm1Mom/Tcrb⁺ Tcrd^tm1Mom/Tcrd^tm1Mom Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Gt(ROSA)26Sor^{tm11(Lmp1)Rsky} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tcrb^tm1Mom mutation (12 available); any Tcrb mutation (97 available)
Tcrd^tm1Mom mutation (13 available); any Tcrd mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:181546 )

immune system

enlarged spleen ( J:181546 )

increased B cell number ( J:181546 )

hematopoietic system

enlarged spleen ( J:181546 )

increased B cell number ( J:181546 )

growth/size/body

enlarged spleen ( J:181546 )

Allelic Composition	Gt(ROSA)26Sor^{tm11(Lmp1)Rsky}/Gt(ROSA)26Sor⁺ Tcrb^tm1Mom/Tcrb^tm1Mom Tcrd^tm1Mom/Tcrd^tm1Mom Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:181546 )

immune system

enlarged spleen ( J:181546 )

increased B cell number ( J:181546 )

liver/biliary system

enlarged liver ( J:181546 )

• occasionally

neoplasm

increased B cell derived lymphoma incidence ( J:181546 )

• most tumors resemble diffuse large B cell lymphomas (in 6 of 9 mice)

increased plasmacytoma incidence ( J:181546 )

• in 3 of 9 mice

hematopoietic system

enlarged spleen ( J:181546 )

increased B cell number ( J:181546 )

growth/size/body

enlarged liver ( J:181546 )

• occasionally

enlarged spleen ( J:181546 )

Allelic Composition	Gt(ROSA)26Sor^{tm11(Lmp1)Rsky}/Gt(ROSA)26Sor⁺ Klrk1^tm1Dhr/Klrk1^tm1Dhr Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Gt(ROSA)26Sor^{tm11(Lmp1)Rsky} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Klrk1^tm1Dhr mutation (3 available); any Klrk1 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:181546 )

N	• mice are protected from Lmp1-driven lymphomagenesis

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:181546 )

• 2 weeks after treatment with a cocktail of depleting antibodies (anti-CD4, anti-CD8 and anti-Thy1)

immune system

enlarged spleen ( J:181546 )

• 2 weeks after treatment with a cocktail of depleting antibodies (anti-CD4, anti-CD8 and anti-Thy1)

abnormal B cell differentiation ( J:181546 )

• impaired in the bone marrow

increased pro-B cell number ( J:181546 )

• at 6 to 12 weeks in the bone marrow

decreased B cell number ( J:181546 )

• at 6 to 12 weeks in the spleen and bone marrow

• absent CD19+Fas+ B cells at 8 to 11 weeks in the spleen

decreased mature B cell number ( J:181546 )

• at 6 to 12 weeks in the bone marrow

decreased pre-B cell number ( J:181546 )

• at 6 to 12 weeks in the bone marrow

increased B cell number ( J:181546 )

• at P8, mice exhibit an increase in CD19+ B cells in the spleen compared with control mice

increased CD4-positive, alpha-beta T cell number ( J:181546 )

• at P8, but not P3, in the spleen

• of activated T cells in the bone marrow at 6 to 12 weeks

increased CD8-positive, alpha-beta T cell number ( J:181546 )

• at P8, but not P3, in the spleen

• of activated T cells in the bone marrow at 6 to 12 weeks

abnormal immune system physiology ( J:181546 )

• after 2 weeks, mice treated with a cocktail of depleting antibodies (anti-CD4, anti-CD8 and anti-Thy1) exhibit splenomegaly and become terminally ill unlike control mice

increased B cell proliferation ( J:181546 )

• after 2 weeks, mice treated with a cocktail of depleting antibodies (anti-CD4, anti-CD8 and anti-Thy1) exhibit rapid expansion of Lmp1+ B cell blasts largely confined to peripheral lymphoid organs and the bone marrow with some infiltration into the liver and rarely into lungs and kidneys compared with control mice

• however, mice treated with one depleting antibodies (anti-CD4, anti-CD8, anti-Thy1 or anti-CD4 and anti-CD8) do not exhibit expansion of B cells

abnormal CD4-positive, alpha-beta T cell physiology ( J:181546 )

• in an in vitro tumor killing assay, CD4+ T cells exhibit reduced tumor killing compared with control cells

• however, CD4+ T cells exhibit normal prevention of tumor outgrowth in vivo and elimination of nontransformed L,p1+ B cells upon transfer

abnormal CD8-positive, alpha-beta T cell physiology ( J:181546 )

• the CD8+ compartment of the bone marrow of mice treated with a cocktail of depleting antibodies (anti-CD4, anti-CD8 and anti-Thy1) exhibit a 2-fold increase in cells expressing IFN-gamma, TNF-alpha, IL4 and IL17

• in vivo, CD8+ T cells exhibit reduced prevention of tumor outgrowth compared with control cells

• however, CD8+ T cell exhibit normal tumor killing in vitro and elimination of nontransformed L,p1+ B cells upon transfer

increased interferon-gamma secretion ( J:181546 )

• minor in T cells co-cultured with tumor or B cells

increased tumor necrosis factor secretion ( J:181546 )

• minor in T cells co-cultured with tumor or B cells

hematopoietic system

increased B cell proliferation ( J:181546 )

• however, mice treated with one depleting antibodies (anti-CD4, anti-CD8, anti-Thy1 or anti-CD4 and anti-CD8) do not exhibit expansion of B cells

enlarged spleen ( J:181546 )

• 2 weeks after treatment with a cocktail of depleting antibodies (anti-CD4, anti-CD8 and anti-Thy1)

abnormal B cell differentiation ( J:181546 )

• impaired in the bone marrow

increased pro-B cell number ( J:181546 )

• at 6 to 12 weeks in the bone marrow

decreased B cell number ( J:181546 )

• at 6 to 12 weeks in the spleen and bone marrow

• absent CD19+Fas+ B cells at 8 to 11 weeks in the spleen

decreased mature B cell number ( J:181546 )

• at 6 to 12 weeks in the bone marrow

decreased pre-B cell number ( J:181546 )

• at 6 to 12 weeks in the bone marrow

increased B cell number ( J:181546 )

• at P8, mice exhibit an increase in CD19+ B cells in the spleen compared with control mice

increased CD4-positive, alpha-beta T cell number ( J:181546 )

• at P8, but not P3, in the spleen

• of activated T cells in the bone marrow at 6 to 12 weeks

increased CD8-positive, alpha-beta T cell number ( J:181546 )

• at P8, but not P3, in the spleen

• of activated T cells in the bone marrow at 6 to 12 weeks

abnormal CD4-positive, alpha-beta T cell physiology ( J:181546 )

• in an in vitro tumor killing assay, CD4+ T cells exhibit reduced tumor killing compared with control cells

• however, CD4+ T cells exhibit normal prevention of tumor outgrowth in vivo and elimination of nontransformed L,p1+ B cells upon transfer

abnormal CD8-positive, alpha-beta T cell physiology ( J:181546 )

• in vivo, CD8+ T cells exhibit reduced prevention of tumor outgrowth compared with control cells

• however, CD8+ T cell exhibit normal tumor killing in vitro and elimination of nontransformed L,p1+ B cells upon transfer

growth/size/body

enlarged spleen ( J:181546 )

• 2 weeks after treatment with a cocktail of depleting antibodies (anti-CD4, anti-CD8 and anti-Thy1)

cellular

increased B cell proliferation ( J:181546 )

• however, mice treated with one depleting antibodies (anti-CD4, anti-CD8, anti-Thy1 or anti-CD4 and anti-CD8) do not exhibit expansion of B cells

Allelic Composition	Gt(ROSA)26Sor^{tm11(Lmp1)Rsky}/Gt(ROSA)26Sor⁺ Cd19^{tm1(cre/ERT2)Rsky}/Cd19⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^{tm1(cre/ERT2)Rsky} mutation (1 available); any Cd19 mutation (60 available)
Gt(ROSA)26Sor^{tm11(Lmp1)Rsky} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

enlarged spleen ( J:217520 )

• with B cell blasts outnumbering normal splenic B cells 20-fold in tamoxifen-treated mice

increased B cell number ( J:217520 )

• CD19+ B cells in tamoxifen-treated mice

• B cell blasts outnumbering normal splenic B cells 20-fold in tamoxifen-treated mice

• however, cell counts return to baseline after 2 weeks and a second application of tamoxifen does not result in another wave of B cell expansion

increased CD4-positive, alpha-beta T cell number ( J:217520 )

• massive expansion in tamoxifen-treated mice

increased CD8-positive, alpha-beta T cell number ( J:217520 )

• massive expansion in tamoxifen-treated mice

increased activated T cell number ( J:217520 )

• in tamoxifen-treated mice

• however, T cell numbers decrease 8 days after tamoxifen application

abnormal T cell physiology ( J:217520 )

• vigorous degranulation when T cells from tamoxifen-treated mice are exposed to LMP1-transduced B cells in vitro

hematopoietic system

enlarged spleen ( J:217520 )

• with B cell blasts outnumbering normal splenic B cells 20-fold in tamoxifen-treated mice

increased B cell number ( J:217520 )

• CD19+ B cells in tamoxifen-treated mice

• B cell blasts outnumbering normal splenic B cells 20-fold in tamoxifen-treated mice

• however, cell counts return to baseline after 2 weeks and a second application of tamoxifen does not result in another wave of B cell expansion

increased CD4-positive, alpha-beta T cell number ( J:217520 )

• massive expansion in tamoxifen-treated mice

increased CD8-positive, alpha-beta T cell number ( J:217520 )

• massive expansion in tamoxifen-treated mice

increased activated T cell number ( J:217520 )

• in tamoxifen-treated mice

• however, T cell numbers decrease 8 days after tamoxifen application

abnormal T cell physiology ( J:217520 )

• vigorous degranulation when T cells from tamoxifen-treated mice are exposed to LMP1-transduced B cells in vitro

growth/size/body

enlarged spleen ( J:217520 )

• with B cell blasts outnumbering normal splenic B cells 20-fold in tamoxifen-treated mice

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