Phenotypes associated with this allele

• Allele Symbol: Clec1b^tm1.2Arte
• Allele Name: targeted mutation 1.2, TaconicArtemis
• Allele ID: MGI:5314118
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Clec1b^tm1.2Arte/Clec1b^tm1.2Arte	involves: 129 * C57BL/6	MGI:5314121
hm2	Clec1b^tm1.2Arte/Clec1b^tm1.2Arte	Not Specified	MGI:5314233

Genotype
MGI:5314121

hm1

• Allelic Composition: Clec1b^tm1.2Arte/Clec1b^tm1.2Arte
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:181754 )

• 4 of over 150 mice survive to 4 weeks of age but are extremely sick and have to be sacrificed

perinatal lethality, incomplete penetrance ( J:181754 )

• most mice die in late gestation or shortly after birth

neonatal lethality, incomplete penetrance ( J:181754 )

• most mice die in late gestation or shortly after birth

homeostasis/metabolism

abnormal platelet physiology ( J:181754 )

• platelets isolated from irradiated mice reconstituted with fetal livers from knock-out mice fail to respond to CLEC1B-agonists unlike control cells

• however, tail bleeding and aggregation on collagen are normal

hematopoietic system

abnormal platelet physiology ( J:181754 )

• platelets isolated from irradiated mice reconstituted with fetal livers from knock-out mice fail to respond to CLEC1B-agonists unlike control cells

• however, tail bleeding and aggregation on collagen are normal

Genotype
MGI:5314233

hm2

• Allelic Composition: Clec1b^tm1.2Arte/Clec1b^tm1.2Arte
• Genetic Background: Not Specified

mortality/aging

premature death ( J:181715 )

• the 3 of 205 mice that survive up to P30 were euthanized due to deteriorating condition

perinatal lethality, incomplete penetrance ( J:181715 )

• mice with respiratory distress die by P1

neonatal lethality, incomplete penetrance ( J:181715 )

• fewer than expected mice are found at P0

• however, 3 of 205 mice survive up to P30

cardiovascular system

abnormal brain vasculature morphology ( J:181715 )

• mice exhibit a connection between the vasculature and lymphatic systems

intracranial hemorrhage ( J:181715 )

• in the brain (at least 1 ventricle and parenchyma) at E12.5 persisting through E18.5

spinal hemorrhage ( J:181715 )

• at E12.5 persisting through E18.5

skin hemorrhage ( J:181715 )

• occasional discreet hemorrhages in the skin

respiratory system

abnormal lung morphology ( J:181715 )

• larger airways contain fluid droplets unlike in wild-type mice

primary atelectasis ( J:181715 )

• some terminal air sacs fail to properly inflate

respiratory distress ( J:181715 )

• in most mice that die between birth and P1

homeostasis/metabolism

decreased platelet aggregation ( J:181715 )

• abrogated

edema ( J:181715 )

• throughout the back and limbs from E14.5

• edematous swelling at birth

chylous ascites ( J:181715 )

• chylous ascites in the abdomen of newborns that survive long enough to feed

immune system

abnormal lymphatic vessel morphology ( J:181715 )

• between E14.5 and E18.5, mice exhibit blood-filled lymphatic vessels in the skin unlike in wild-type mice

• at P0, lymphatic vessels in the lungs contain blood cells unlike in wild-type mice

• mice exhibit a connection between the vasculature and lymphatic systems

• when fetal livers are used to reconstitute irradiated wild-type mice, chimeras exhibit loss of lymphatic vessel integrity compared with wild-type mice

decreased lymphatic vessel endothelial cell number ( J:181715 )

• at E16.5, E18.5 and P0, the ratio of lymphatic endothelial cells to blood endothelial cells is reduced in the mesenteric vessels surrounding the intestine, the intestine proper and lungs compared to in wild-type mice

nervous system

abnormal brain vasculature morphology ( J:181715 )

• mice exhibit a connection between the vasculature and lymphatic systems

intracranial hemorrhage ( J:181715 )

• in the brain (at least 1 ventricle and parenchyma) at E12.5 persisting through E18.5

spinal hemorrhage ( J:181715 )

• at E12.5 persisting through E18.5

integument

skin hemorrhage ( J:181715 )

• occasional discreet hemorrhages in the skin

hematopoietic system

decreased platelet aggregation ( J:181715 )

• abrogated