Phenotypes associated with this allele

• Allele Symbol: Ceacam2^tm1Snaj
• Allele Name: targeted mutation 1, Sonia M Najjar
• Allele ID: MGI:5314388
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ceacam2^tm1Snaj/Ceacam2^tm1Snaj	involves: 129S4/SvJae * C57BL/6	MGI:5314391

Genotype
MGI:5314391

hm1

• Allelic Composition: Ceacam2^tm1Snaj/Ceacam2^tm1Snaj
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:181979 )

N • male mice exhibit normal glucose homeostasis

N • mice exhibit normal insulin clearance, basal glucose levels and hepatic glucose homeostasis

decreased fatty acid oxidation ( J:181979 )

♀ • decreased in the muscle of fasted female mice

increased circulating leptin level ( J:181979 )

♀ • in female mice at 4 months

decreased circulating triglyceride level ( J:181979 )

♀ • in fasting female mice at 2 months

decreased energy expenditure ( J:181979 )

♀ • in female mice at 6 months, even after fasting and refeeding

decreased carbon dioxide production ( J:181979 )

♀ • in female mice at 6 months

decreased oxygen consumption ( J:181979 )

♀ • female mice at 6 months

decreased respiratory quotient ( J:181979 )

♀ • in female mice after fasting and refeeding

abnormal glucose homeostasis ( J:181979 )

♀ • female mice exhibit reduced whole body glucose turnover compared with wild-type mice

increased insulin secretion ( J:181979 )

♀ • in female mice

increased circulating insulin level ( J:181979 )

♀ • in female mice at 2 months

impaired glucose tolerance ( J:181979 )

♀ • in female mice

abnormal glycogen homeostasis ( J:181979 )

♀ • female mice exhibit reduced glycogen/lipid synthesis compared with wild-type mice

insulin resistance ( J:181979 )

♀ • in female mice

increased skeletal muscle triglyceride level ( J:181979 )

♀ • in the muscles of female mice

growth/size/body

growth/size/body region phenotype ( J:181979 )

♂N • male mice exhibit normal body weight

increased lean body mass ( J:181979 )

♀ • in female mice starting at 2 months

obese ( J:181979 )

♀ • in female mice starting at 2 months

adipose tissue

increased total body fat amount ( J:181979 )

♀ • in female mice starting at 2 months

increased abdominal fat pad weight ( J:181979 )

♀ • in female mice after 4 months

behavior/neurological

polyphagia ( J:181979 )

♀ • in female mice by 3 months

muscle

decreased skeletal muscle cell glucose uptake ( J:181979 )

♀ • female mice exhibit lower insulin-stimulated glucose uptake in skeletal muscle compared with wild-type mice

increased skeletal muscle triglyceride level ( J:181979 )

♀ • in the muscles of female mice

cellular

decreased skeletal muscle cell glucose uptake ( J:181979 )

♀ • female mice exhibit lower insulin-stimulated glucose uptake in skeletal muscle compared with wild-type mice

decreased fatty acid oxidation ( J:181979 )

♀ • decreased in the muscle of fasted female mice

endocrine/exocrine glands

increased insulin secretion ( J:181979 )

♀ • in female mice