Analysis Tools
growth/size/body
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• the body weight of adult mice with this transgene is ~10% greater than that of wild-type controls
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homeostasis/metabolism
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• fasting blood glucose is lower in 2 month old mice with this transgene than in wild-type controls (80 +/- 18 mg/dl vs. 105 +/- 33 mg/dl)
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• fasting plasma insulin is significantly lower in mice with this transgene than in wild-type controls
• insulin levels of transgenic mice are significantly lower than those of wild-type controls 30 min after a glucose challenge
• insulin levels are lower in transgenic than in wild-type mice even when the glucose level has been clamped at 10mM for 120 min
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• 8-10 week old mice with this transgene exhibit significantly lower plasma glucose levels than wild-type controls at all time points of a glucose tolerance test
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• mice with this transgene exhibit significantly greater glucose clearance than wild-type controls in an insulin tolerance test
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