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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Spata22repro42
reproductive mutant 42, JAX Reproductive Mutagenesis Program
MGI:5314540
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Spata22repro42/Spata22repro42 C3.B6-Spata22repro42 MGI:6280313
hm2
 		Spata22repro42/Spata22repro42 involves: C3HeB/FeJ * C57BL/6J MGI:5315472
ht3
 		Spata22repro42/Spata22tm1a(KOMP)Wtsi involves: C3H * C57BL/6N MGI:6280314


Genotype
MGI:6280313
hm1
Allelic
Composition		 Spata22repro42/Spata22repro42
Genetic
Background		 C3.B6-Spata22repro42
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spata22repro42 mutation (0 available); any Spata22 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
decreased oocyte number ( J:249350 )
• adult ovaries show severe loss of oocytes
decreased male germ cell number ( J:249350 )
• adult testes show severe loss of germ cells
ovary cyst ( J:249350 )
• cysts are observed in some adult ovaries

cellular
decreased oocyte number ( J:249350 )
• adult ovaries show severe loss of oocytes
decreased male germ cell number ( J:249350 )
• adult testes show severe loss of germ cells

endocrine/exocrine glands
ovary cyst ( J:249350 )
• cysts are observed in some adult ovaries

growth/size/body
ovary cyst ( J:249350 )
• cysts are observed in some adult ovaries




Genotype
MGI:5315472
hm2
Allelic
Composition		 Spata22repro42/Spata22repro42
Genetic
Background		 involves: C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spata22repro42 mutation (0 available); any Spata22 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal spermatocyte morphology ( J:182054 )
• mice lack some stages of spermatocytes
abnormal female meiosis ( J:182054 )
• meiotic arrest with impaired synapsis and DNA repair
ovary cyst ( J:182054 )
• hemorrhagic cysts
arrest of male meiosis ( J:182054 )
• at prophase I with impaired synapsis and DNA repair

cellular
abnormal spermatocyte morphology ( J:182054 )
• mice lack some stages of spermatocytes
abnormal female meiosis ( J:182054 )
• meiotic arrest with impaired synapsis and DNA repair
arrest of male meiosis ( J:182054 )
• at prophase I with impaired synapsis and DNA repair
abnormal double-strand DNA break repair ( J:182054 )
• impaired in oocytes and spermatocytes

endocrine/exocrine glands
ovary cyst ( J:182054 )
• hemorrhagic cysts

homeostasis/metabolism
abnormal double-strand DNA break repair ( J:182054 )
• impaired in oocytes and spermatocytes

growth/size/body
ovary cyst ( J:182054 )
• hemorrhagic cysts




Genotype
MGI:6280314
ht3
Allelic
Composition		 Spata22repro42/Spata22tm1a(KOMP)Wtsi
Genetic
Background		 involves: C3H * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spata22repro42 mutation (0 available); any Spata22 mutation (31 available)
Spata22tm1a(KOMP)Wtsi mutation (1 available); any Spata22 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
absent oocytes ( J:249350 )
• adult ovaries show complete lack of oocytes
decreased male germ cell number ( J:249350 )
• adult males exhibit an absence of certain spermatocytes, spermatids, and spermatozoa
arrest of male meiosis ( J:249350 )
• severe male germ cell depletion is caused by meiotic arrest
abnormal ovarian follicle morphology ( J:249350 )
• adult ovaries contain degenerated follicles
small ovary ( J:249350 )
• adult females exhibit smaller ovaries
small testis ( J:249350 )
• adult males exhibit smaller testes
infertility ( J:249350 )
• both males and females are sterile but otherwise overtly normal

cellular
absent oocytes ( J:249350 )
• adult ovaries show complete lack of oocytes
decreased male germ cell number ( J:249350 )
• adult males exhibit an absence of certain spermatocytes, spermatids, and spermatozoa
arrest of male meiosis ( J:249350 )
• severe male germ cell depletion is caused by meiotic arrest

endocrine/exocrine glands
abnormal ovarian follicle morphology ( J:249350 )
• adult ovaries contain degenerated follicles
small ovary ( J:249350 )
• adult females exhibit smaller ovaries
small testis ( J:249350 )
• adult males exhibit smaller testes

growth/size/body
ovary cyst ( J:249350 )




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10/29/2024
MGI 6.24 		The Jackson Laboratory