All Phenotypes Car5b<tm1Sly> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Car5b^tm1Sly
targeted mutation 1, William S Sly
MGI:5314752

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Car5b^tm1Sly/Car5b^tm1Sly	involves: 129S1/Sv * C57BL/6	MGI:5515770
cx2	Car5a^tm1Sly/Car5a^tm1Sly Car5b^tm1Sly/Car5b^tm1Sly	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5515773
cx3	Car5a^tm1Sly/Car5a^tm1Sly Car5b^tm1Sly/Y	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5515774
ot4	Car5b^tm1Sly/Y	involves: 129S1/Sv * C57BL/6	MGI:5515772

Allelic Composition	Car5b^tm1Sly/Car5b^tm1Sly
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Car5b^tm1Sly mutation (1 available); any Car5b mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:196135 )

N	• normal survival

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:196135 )

N	• blood glucose levels are like controls both when fed and while fasting • blood ammonia levels are normal

Allelic Composition	Car5a^tm1Sly/Car5a^tm1Sly Car5b^tm1Sly/Car5b^tm1Sly
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Car5a^tm1Sly mutation (1 available); any Car5a mutation (15 available)
Car5b^tm1Sly mutation (1 available); any Car5b mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:196135 )

• females are significantly smaller than controls

mortality/aging

premature death ( J:196135 )

• die prematurely beginning shortly after weaning

preweaning lethality, incomplete penetrance ( J:196135 )

• 11 females compared to 17 for controls

homeostasis/metabolism

increased circulating ammonia level ( J:196135 )

• significantly elevated, higher than in Car5a^tm1Sly homozygotes

decreased circulating glucose level ( J:196135 )

• fasting blood sugar is significantly lower than in controls

• blood sugar is similar to controls when fed

cellular

oxidative stress ( J:181790 )

• reduced oxidative stress in the brain

• elevated levels of glutathione

• reduced SOD, HNE, and 3-NT

Allelic Composition	Car5a^tm1Sly/Car5a^tm1Sly Car5b^tm1Sly/Y
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:196135 )

• males are significantly smaller than controls

mortality/aging

premature death ( J:196135 )

• die prematurely beginning shortly after weaning

• males die more rapidly than females

preweaning lethality, incomplete penetrance ( J:196135 )

• 38 males compared to 84 for controls

homeostasis/metabolism

increased circulating ammonia level ( J:196135 )

• significantly elevated, higher than in Car5a^tm1Sly homozygotes

decreased circulating glucose level ( J:196135 )

• fasting blood sugar is significantly lower than in controls

• blood sugar is similar to controls when fed

cellular

oxidative stress ( J:181790 )

• reduced oxidative stress in the brain

• elevated levels of glutathione

• reduced SOD, HNE, and 3-NT

Allelic Composition	Car5b^tm1Sly/Y
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Car5b^tm1Sly mutation (1 available); any Car5b mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:196135 )

N	• normal survival

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:196135 )

N	• blood glucose levels are like controls both when fed and while fasting • blood ammonia levels are normal

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