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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Car5btm1Sly
targeted mutation 1, William S Sly
MGI:5314752
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Car5btm1Sly/Car5btm1Sly involves: 129S1/Sv * C57BL/6 MGI:5515770
cx2
Car5atm1Sly/Car5atm1Sly
Car5btm1Sly/Car5btm1Sly
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5515773
cx3
Car5atm1Sly/Car5atm1Sly
Car5btm1Sly/Y
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5515774
ot4
Car5btm1Sly/Y involves: 129S1/Sv * C57BL/6 MGI:5515772


Genotype
MGI:5515770
hm1
Allelic
Composition
Car5btm1Sly/Car5btm1Sly
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Car5btm1Sly mutation (1 available); any Car5b mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• normal survival

homeostasis/metabolism
N
• blood glucose levels are like controls both when fed and while fasting
• blood ammonia levels are normal




Genotype
MGI:5515773
cx2
Allelic
Composition
Car5atm1Sly/Car5atm1Sly
Car5btm1Sly/Car5btm1Sly
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Car5atm1Sly mutation (1 available); any Car5a mutation (15 available)
Car5btm1Sly mutation (1 available); any Car5b mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• females are significantly smaller than controls

mortality/aging
• die prematurely beginning shortly after weaning
• 11 females compared to 17 for controls

homeostasis/metabolism
• significantly elevated, higher than in Car5atm1Sly homozygotes
• fasting blood sugar is significantly lower than in controls
• blood sugar is similar to controls when fed

cellular
• reduced oxidative stress in the brain
• elevated levels of glutathione
• reduced SOD, HNE, and 3-NT




Genotype
MGI:5515774
cx3
Allelic
Composition
Car5atm1Sly/Car5atm1Sly
Car5btm1Sly/Y
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Car5atm1Sly mutation (1 available); any Car5a mutation (15 available)
Car5btm1Sly mutation (1 available); any Car5b mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• males are significantly smaller than controls

mortality/aging
• die prematurely beginning shortly after weaning
• males die more rapidly than females
• 38 males compared to 84 for controls

homeostasis/metabolism
• significantly elevated, higher than in Car5atm1Sly homozygotes
• fasting blood sugar is significantly lower than in controls
• blood sugar is similar to controls when fed

cellular
• reduced oxidative stress in the brain
• elevated levels of glutathione
• reduced SOD, HNE, and 3-NT




Genotype
MGI:5515772
ot4
Allelic
Composition
Car5btm1Sly/Y
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Car5btm1Sly mutation (1 available); any Car5b mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• normal survival

homeostasis/metabolism
N
• blood glucose levels are like controls both when fed and while fasting
• blood ammonia levels are normal





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory