Analysis Tools|
Allele Symbol Allele Name Allele ID |
Srctm1Mul targeted mutation 1, William J Muller MGI:5314758 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Normal mammary gland branching and ductal outgrowth in Srctm1Mul/Srctm1Mul Tg(MMTV-cre)7Mul/0 mice
| N |
• mice exhibit normal mammary gland branching and ductal outgrowth
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Analysis of tumorigenesis
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• with later onset than in Tg(MMTV-PyVT)#Mul mice
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• with later onset than in Tg(MMTV-PyVT)#Mul mice
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• with later onset than in Tg(MMTV-PyVT)#Mul mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Analysis of tumorigenesis
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• with later onset and decreased tumor burden than in Tg(MMTV-PyVT)#Mul mice
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• with later onset and decreased tumor burden than in Tg(MMTV-PyVT)#Mul mice
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• with later onset and decreased tumor burden than in Tg(MMTV-PyVT)#Mul mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• of tumor cells transfected with a retrovirus expressing a tamoxifen-dependent cre and treated with tamoxifen
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• of tumor cells transfected with a retrovirus expressing a tamoxifen-dependent cre and treated with tamoxifen
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• tumor cells transfected with a retrovirus expressing a tamoxifen-dependent cre and treated with tamoxifen exhibit impaired proliferation, increased apoptosis and restored cell-cell adhesion compared to in Tg(MMTV-PyVT)#Mul mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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