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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lhx8tm2.1Vpa
targeted mutation 2.1, Vassilis Pachnis
MGI:5314801
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Lhx8tm1Vpa/Lhx8tm2.1Vpa
Tmem163Tg(ACTB-cre)2Mrt/0 		involves: 129P2/OlaHsd * 129S4/SvJae * FVB/N MGI:5314802
cn2
 		Lhx8tm1Vpa/Lhx8tm2.1Vpa
Tg(Chat-cre)GM24Gsat/0 		involves: 129P2/OlaHsd * 129S4/SvJae * FVB/N MGI:5314803


Genotype
MGI:5314802
cn1
Allelic
Composition		 Lhx8tm1Vpa/Lhx8tm2.1Vpa
Tmem163Tg(ACTB-cre)2Mrt/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx8tm1Vpa mutation (0 available); any Lhx8 mutation (25 available)
Lhx8tm2.1Vpa mutation (0 available); any Lhx8 mutation (25 available)
Tmem163Tg(ACTB-cre)2Mrt mutation (3 available); any Tmem163 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal brain interneuron morphology ( J:182013 )
• cholinergic striatal interneurons are dramatically reduced in the striatum and this is associated with an increase in Lhx6 expressing striatal interneurons
abnormal striatum morphology ( J:182013 )
• cholinergic striatal interneurons are dramatically reduced in the striatum and this is associated with an increase in Lhx6 expressing striatal interneurons




Genotype
MGI:5314803
cn2
Allelic
Composition		 Lhx8tm1Vpa/Lhx8tm2.1Vpa
Tg(Chat-cre)GM24Gsat/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx8tm1Vpa mutation (0 available); any Lhx8 mutation (25 available)
Lhx8tm2.1Vpa mutation (0 available); any Lhx8 mutation (25 available)
Tg(Chat-cre)GM24Gsat mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal striatum morphology ( J:182013 )
• cholinergic striatal interneurons are severely reduced in the striatum
abnormal neuron morphology ( J:182013 )
• small but statistically significant reduction in the nuclear size of ChAT+ neurons in the striatum
abnormal neuron differentiation ( J:182013 )
• potential cholinergic interneurons lose their cholinergic markers and develop into GABAergic interneurons
abnormal brain interneuron morphology ( J:182013 )
• cholinergic striatal interneurons are severely reduced in the striatum
abnormal GABAergic neuron morphology ( J:182013 )
• potential cholinergic interneurons lose their cholinergic markers and develop into GABAergic interneurons
abnormal cholinergic neuron morphology ( J:182013 )
• loss of cholinergic neurons in the striatum

cellular
abnormal neuron differentiation ( J:182013 )
• potential cholinergic interneurons lose their cholinergic markers and develop into GABAergic interneurons




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory