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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Huwe1tm1.1Mak
targeted mutation 1.1, Tak Mak
MGI:5314816
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cd79atm1(cre)Reth/Cd79a+
Huwe1tm1.1Mak/Y 		B6.Cg-Cd79atm1(cre)Reth Huwe1tm1.1Mak MGI:5314905
cn2
 		Cd79atm1(cre)Reth/Cd79a+
Huwe1tm1.1Mak/Y
Trp53tm1Brn/Trp53tm1Brn 		involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:5314906


Genotype
MGI:5314905
cn1
Allelic
Composition		 Cd79atm1(cre)Reth/Cd79a+
Huwe1tm1.1Mak/Y
Genetic
Background		 B6.Cg-Cd79atm1(cre)Reth Huwe1tm1.1Mak
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Huwe1tm1.1Mak mutation (1 available); any Huwe1 mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased B cell apoptosis ( J:181705 )
• in pre-B cells and mature B cells (1.5-fold)
decreased B cell proliferation ( J:181705 )
• of transitional, marginal zone and follicular B cells
• when B cells are stimulated with anti-IgM or anti-IgM plus anti-CD40
• in B cells stimulated with LPS plus IL4
abnormal B cell differentiation ( J:181705 )
• partially blocked at pre-B stage
abnormal class switch recombination ( J:181705 )
• following stimulation of B cells with LPS or LPS plus IL4
decreased mature B cell number ( J:181705 )
• 3-fold for recirculating mature B cells due to increased apoptosis
• of B220+IgM+ B cells in the spleen
absent B-1a cells ( J:181705 )
• virtually absent in the peritoneal cavity
decreased pre-B cell number ( J:181705 )
• due to increased apoptosis
abnormal humoral immune response ( J:181705 )
• mice stimulated with a T-independent antigen, TNP-Ficoll, fail to mount a TNP-specific IgM or IgG3 unlike control mice
• mice stimulated with a T-dependent antigen, NP(15)CGG, produce less NP-specific IgG1 compared with control mice
decreased IgA level ( J:181705 )
• 4.5-fold in unstimulated mice
decreased IgG1 level ( J:181705 )
• 2-fold in unstimulated mice
• in mice stimulated with NP(15)CGG
decreased IgG2a level ( J:181705 )
• 32-fold in unstimulated mice
decreased IgG3 level ( J:181705 )
• 37-fold in unstimulated mice
• in mice stimulated with TNP-Ficoll
decreased IgM level ( J:181705 )
• 2.5-fold in unstimulated mice
• in mice stimulated with TNP-Ficoll
increased susceptibility to Riboviria infection ( J:181705 )
• mice infected with vesicular stomatitis virus (VSV) exhibit delayed anti-VSV antibody production and reduced anti-VSV IgG levels compared with control mice

cellular
increased B cell apoptosis ( J:181705 )
• in pre-B cells and mature B cells (1.5-fold)
decreased B cell proliferation ( J:181705 )
• of transitional, marginal zone and follicular B cells
• when B cells are stimulated with anti-IgM or anti-IgM plus anti-CD40
• in B cells stimulated with LPS plus IL4

hematopoietic system
increased B cell apoptosis ( J:181705 )
• in pre-B cells and mature B cells (1.5-fold)
decreased B cell proliferation ( J:181705 )
• of transitional, marginal zone and follicular B cells
• when B cells are stimulated with anti-IgM or anti-IgM plus anti-CD40
• in B cells stimulated with LPS plus IL4
abnormal B cell differentiation ( J:181705 )
• partially blocked at pre-B stage
abnormal class switch recombination ( J:181705 )
• following stimulation of B cells with LPS or LPS plus IL4
decreased mature B cell number ( J:181705 )
• 3-fold for recirculating mature B cells due to increased apoptosis
• of B220+IgM+ B cells in the spleen
absent B-1a cells ( J:181705 )
• virtually absent in the peritoneal cavity
decreased pre-B cell number ( J:181705 )
• due to increased apoptosis
decreased IgA level ( J:181705 )
• 4.5-fold in unstimulated mice
decreased IgG1 level ( J:181705 )
• 2-fold in unstimulated mice
• in mice stimulated with NP(15)CGG
decreased IgG2a level ( J:181705 )
• 32-fold in unstimulated mice
decreased IgG3 level ( J:181705 )
• 37-fold in unstimulated mice
• in mice stimulated with TNP-Ficoll
decreased IgM level ( J:181705 )
• 2.5-fold in unstimulated mice
• in mice stimulated with TNP-Ficoll




Genotype
MGI:5314906
cn2
Allelic
Composition		 Cd79atm1(cre)Reth/Cd79a+
Huwe1tm1.1Mak/Y
Trp53tm1Brn/Trp53tm1Brn
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Huwe1tm1.1Mak mutation (1 available); any Huwe1 mutation (63 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:181705 )
N
• bone marrow B cell development and stimulated and unstimulated splenic B cell proliferation are restored compared to in Cd79atm1(cre)Reth/Cd79a+ Huwe1tm1.1Mak/Y mice
abnormal class switch recombination ( J:181705 )
• to a greater extent than in Cd79atm1(cre)Reth/Cd79a+ Huwe1tm1.1Mak/Y mice following stimulation of B cells with LPS or LPS plus IL4
absent B-1a cells ( J:181705 )
• virtually absent in the peritoneal cavity

hematopoietic system
abnormal class switch recombination ( J:181705 )
• to a greater extent than in Cd79atm1(cre)Reth/Cd79a+ Huwe1tm1.1Mak/Y mice following stimulation of B cells with LPS or LPS plus IL4
absent B-1a cells ( J:181705 )
• virtually absent in the peritoneal cavity




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory