Phenotypes associated with this allele

• Allele Symbol: Grin2b^tm1.1Jwhe
• Allele Name: targeted mutation 1.1, Johannes W Hell
• Allele ID: MGI:5314923
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grin2b^tm1.1Jwhe/Grin2b^tm1.1Jwhe	B6JBomTac.129P2-Grin2b^tm1.1Jwhe	MGI:5314940

Genotype
MGI:5314940

hm1

• Allelic Composition: Grin2b^tm1.1Jwhe/Grin2b^tm1.1Jwhe
• Genetic Background: B6JBomTac.129P2-Grin2b^tm1.1Jwhe

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:181943 )

N • mice exhibit normal learning in a Morris water maze, activity levels, anxiety-related behavior, coordination and working memory in a radial arm maze

abnormal temporal memory ( J:181943 )

• in a Morris water maze, mice exhibit impaired early phase of contextual memory consolidation and maintenance compared with wild-type mice

nervous system

nervous system phenotype ( J:181943 )

N • mice exhibit normal basal synaptic transmission and long term depression

reduced long-term potentiation ( J:181943 )

• induced by two tetani of 100 Hz/s, theta burst stimulation or a 10 Hz/5s stimulus train in adult mice